Significant increase of CKS1B amplification from monoclonal gammopathy of undetermined significance to multiple myeloma and plasma cell leukaemia as demonstrated by interphase fluorescence in situ hybridisation

Hong Chang

Department of Laboratory Hematology

Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, ON, Canada

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Joanna Yeung,

Joanna Yeung

Department of Laboratory Hematology

Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, ON, Canada

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Wei Xu,

Wei Xu

Department of Laboratory Hematology

Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, ON, Canada

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Yi Ning,

Yi Ning

Department of Cytogenetics, University of Maryland, Baltimore, MD, USA

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Bruce Patterson,

Bruce Patterson

Department of Laboratory Hematology

Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, ON, Canada

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Hong Chang,

Hong Chang

Department of Laboratory Hematology

Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, ON, Canada

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Joanna Yeung,

Joanna Yeung

Department of Laboratory Hematology

Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, ON, Canada

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Wei Xu,

Wei Xu

Department of Laboratory Hematology

Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, ON, Canada

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Yi Ning,

Yi Ning

Department of Cytogenetics, University of Maryland, Baltimore, MD, USA

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Bruce Patterson,

Bruce Patterson

Department of Laboratory Hematology

Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, ON, Canada

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First published: 18 August 2006

https://doi.org/10.1111/j.1365-2141.2006.06237.x

Citations: 28

Hong Chang, Department of Laboratory Hematology, 200 Elizabeth St, 11E-413, Toronto General Hospital, University Health Network, Toronto, ON M5G 2C4, Canada. E-mail: [email protected]

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Summary

The genetic events that lead to tumour progression in plasma cell dyscrasia are not well understood. Interphase cytoplasmic fluorescence in situ hybridisation was used to investigate the CKS1B amplification status (at 1q21) in clonal plasma cells from 123 patients: 23 monoclonal gammopathy of undetermined significance (MGUS), 75 multiple myeloma (MM) and 26 plasma cell leukaemia (PCL). While CKS1B amplification was absent in MGUS patients, such amplification (3–8 copies) was detected in 36% of newly diagnosed MM, 52% relapsed MM and 62% PCL (P < 0·001). Our results suggest that CKS1B amplification is associated with transformation from MGUS to MM and progression to PCL.

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Volume134, Issue6

September 2006

Pages 613-615

Significant increase of CKS1B amplification from monoclonal gammopathy of undetermined significance to multiple myeloma and plasma cell leukaemia as demonstrated by interphase fluorescence in situ hybridisation

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Significant increase of CKS1B amplification from monoclonal gammopathy of undetermined significance to multiple myeloma and plasma cell leukaemia as demonstrated by interphase fluorescence in situ hybridisation

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