Volume 206, Issue 1 pp. 219-231

Innate and adaptive immunity: the Yin and Yang of celiac disease

Bana Jabri

Corresponding Author

Bana Jabri

Department of Pathology, Medicine and Pediatrics, University of Chicago, Chicago, IL, USA.

* Bana Jabri, MD
Department of Pathology, Medicine and
Pediatrics, University of Chicago
5841 South Maryland Avenue – MC 1089
Chicago, IL 60637, USA
Tel.: +1 773 834 8670
Fax: +1 773 702 3701
E-mail: [email protected]Search for more papers by this author
Donald D. Kasarda

Donald D. Kasarda

US Department of Agriculture, Agricultural Research Service, Western Regional Research Center, Albany, CA, USA.

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Peter H. R. Green

Peter H. R. Green

Department of Medicine, Columbia University, College of Physicians and Surgeons, NY, USA.

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First published: 28 July 2005
Citations: 98

Abstract

Summary: Celiac disease is a multigenetic complex inflammatory disorder with an autoimmune component, induced by gluten, a protein found in wheat. It is a unique human disease model to dissect the innate and adaptive immune mechanisms underlying T-cell-mediated tissue destruction and the development of T-cell lymphoma in conditions of chronic T-cell activation.

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