Address correspondence and reprint requests to Dr. A. Schulze-Bonhage at Epilepsy Centre, Neurocentre, University of Freiburg, Breisacher Str. 64, D-79106 Freiburg, Germany. E-mail: [email protected]

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Abstract

Summary: We report a patient with pyridoxine-dependent epileptic seizures during early childhood. She had been completely seizure free for 23 years until she became pregnant. During the week 14 of her pregnancy, status epilepticus developed and was refractory to antiepileptic drugs but responded to intravenous administration of vitamin B₆. Vitamin B₆ levels were found to be decreased during pregnancy, although the patient reported continued and regular oral supplementation. Possible reasons for decreased vitamin B₆ levels leading to status epilepticus are discussed.

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Volume45, Issue1

January 2004

Pages 81-84

Pharmacorefractory Status Epilepticus Due to Low Vitamin B₆ Levels during Pregnancy

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Pharmacorefractory Status Epilepticus Due to Low Vitamin B6 Levels during Pregnancy

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Pharmacorefractory Status Epilepticus Due to Low Vitamin B₆ Levels during Pregnancy