Successful treatment of an elderly patient with severe eosinophilic asthma and eosinophilic myocarditis using benralizumab
Norio Kodaka
Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorChihiro Nakano
Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorTakeshi Oshio
Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorTakatomo Hirouchi
Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorManabu Satou
Division of Cardiovascular Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorMasao Moroi
Division of Cardiovascular Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorToshiaki Oharaseki
Department of Pathology, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Hiroto Matsuse
Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorNorio Kodaka
Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorChihiro Nakano
Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorTakeshi Oshio
Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorTakatomo Hirouchi
Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorManabu Satou
Division of Cardiovascular Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorMasao Moroi
Division of Cardiovascular Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorToshiaki Oharaseki
Department of Pathology, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Hiroto Matsuse
Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
Search for more papers by this authorOpen Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
References
- 1Brambatti M, Matassini MV, Adler ED, Klingel K, Camici PG, Ammirati E. Eosinophilic myocarditis: characteristics, treatment, and outcomes. J Am Coll Cardiol 2017; 70: 2363–2375.
- 2Kawano S, Kato J, Kawano N et al. Clinical features and outcomes of eosinophilic myocarditis patients treated with prednisolone at a single institution over a 27-year period. Inter Med 2011; 50: 975–981.
- 3Schoettler N, Strek ME. Recent advances in severe asthma. Chest 2020; 157: 516–528.
- 4Caminati M, Bagnasco D, Vaia R, Senna G. New horizons for the treatment of severe, eosinophic asthma: benralizumab, a novel precision biologic. Biol Targets Ther 2019; 13: 89.
- 5Legrand F, Klion AD. Biologic therapies targeting eosinophils: current status and future prospects. J Allergy Clin Immunol Pract 2015; 3: 167–174.
- 6Kuang FL, Fay MP, Ware JA et al. Longterm clinical outcomes of high-dose mepolizumab treatment for hypereosinophilic syndrome. J Allergy Clin Immunol Pract 2018; 6: 1518e27.
- 7Kuang FL, Legrand F, Makiya M et al. Benralizumab for PDGFRA-negative hypereosinophilic syndrome. N Engl J Med 2019; 380: 1336e46.
- 8Colantuono S, Pellicano C, Leodori G, Cilia F, Francone M, Visentini M. Early benralizumab for eosinophilic myocarditis in eosinophilic granulomatosis with polyangiitis. Allergol Int 2020; 69: 483–484.