LETTER
Experimental investigations of antiepileptic drugs in astrocytes-microglia co-cultures suggest possible protective effects on astrocytes during early epileptogenesis
Fatme Seval Ismail,
Corresponding Author
Fatme Seval Ismail
Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany
Correspondence
Fatme Seval Ismail, Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Email: [email protected]
Search for more papers by this author Pedro M. Faustmann,
Pedro M. Faustmann
Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Bochum, Germany
International Graduate School of Neuroscience, Ruhr University Bochum, Bochum, Germany
Search for more papers by this author
Fatme Seval Ismail,
Corresponding Author
Fatme Seval Ismail
Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany
Correspondence
Fatme Seval Ismail, Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Email: [email protected]
Search for more papers by this author Pedro M. Faustmann,
Pedro M. Faustmann
Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Bochum, Germany
International Graduate School of Neuroscience, Ruhr University Bochum, Bochum, Germany
Search for more papers by this author
First published: 24 June 2021
No abstract is available for this article.
CONFLICT OF INTEREST
None of the authors has any conflict of interest to disclose. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.
REFERENCES
- 1Wu Z, Deshpande T, Henning L, Bedner P, Seifert G, Steinhäuser C. Cell death of hippocampal CA1 astrocytes during early epileptogenesis. Epilepsia. 2021; 00: 1–15.
- 2Bedner P, Dupper A, Hüttmann K, Müller J, Herde MK, Dublin P, et al. Astrocyte uncoupling as a cause of human temporal lobe epilepsy. Brain. 2015; 138: 1208–22.
- 3Deshpande T, Li T, Henning L, Wu Z, Müller J, Seifert G, et al. Constitutive deletion of astrocytic connexins aggravates kainate-induced epilepsy. Glia. 2020; 68: 2136–47.
- 4Boison D, Steinhäuser C. Epilepsy and astrocyte energy metabolism. Glia. 2018; 66: 1235–43.
- 5Vezzani A, Balosso S, Ravizza T. The role of cytokines in the pathophysiology of epilepsy. Brain Behav Immun. 2008; 22: 797–803.
- 6Galluzzi L, Kepp O, Krautwald S, Kroemer G, Linkermann A. Molecular mechanisms of regulated necrosis. Semin Cell Dev Biol. 2014; 35: 24–32.
- 7Hinkerohe D, Smikalla D, Haghikia A, Heupel K, Haase CG, Dermietzel R, et al. Effects of cytokines on microglial phenotypes and astroglial coupling in an inflammatory coculture model. Glia. 2005; 52: 85–97.
- 8Haghikia A, Ladage K, Hinkerohe D, Vollmar P, Heupel K, Dermietzel R, et al. Implications of antiinflammatory properties of the anticonvulsant drug levetiracetam in astrocytes. J Neurosci Res. 2008; 86: 1781–8.
- 9Dambach H, Hinkerohe D, Prochnow N, Stienen MN, Moinfar Z, Haase CG, et al. Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation. Epilepsia. 2014; 55: 184–92.
- 10Stienen MN, Haghikia A, Dambach H, Thöne J, Wiemann M, Gold R, et al. Anti-inflammatory effects of the anticonvulsant drug levetiracetam on electrophysiological properties of astroglia are mediated via TGFbeta1 regulation. Br J Pharmacol. 2011; 162: 491–507.
- 11Abu-Rish EY, Dahabiyeh LA, Bustanji Y, Mohamed YS, Browning MJ. Effect of lamotrigine on in vivo and in vitro cytokine secretion in murine model of inflammation. J Neuroimmunol. 2018; 322: 36–45.
- 12Pavone A, Cardile V. An in vitro study of new antiepileptic drugs and astrocytes. Epilepsia. 2003; 44: 34–9.