fMRI prediction of naming change after adult temporal lobe epilepsy surgery: Activation matters
Xiaozhen You
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Psychology, Georgetown University, Washington, District of Columbia
Search for more papers by this authorAshley N. Zachery
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Search for more papers by this authorEleanor J. Fanto
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Search for more papers by this authorGina Norato
EEG Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Search for more papers by this authorSierra C. Germeyan
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Search for more papers by this authorEric J. Emery
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Search for more papers by this authorLeigh N. Sepeta
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Search for more papers by this authorMadison M. Berl
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Search for more papers by this authorChelsea L. Black
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Search for more papers by this authorEdythe Wiggs
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Search for more papers by this authorKareem Zaghloul
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Search for more papers by this authorSara K. Inati
EEG Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Search for more papers by this authorWilliam D. Gaillard
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Search for more papers by this authorCorresponding Author
William H. Theodore
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Correspondence
William H. Theodore, Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Email: [email protected]
Search for more papers by this authorXiaozhen You
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Psychology, Georgetown University, Washington, District of Columbia
Search for more papers by this authorAshley N. Zachery
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Search for more papers by this authorEleanor J. Fanto
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Search for more papers by this authorGina Norato
EEG Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Search for more papers by this authorSierra C. Germeyan
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Search for more papers by this authorEric J. Emery
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Search for more papers by this authorLeigh N. Sepeta
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Search for more papers by this authorMadison M. Berl
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Search for more papers by this authorChelsea L. Black
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Search for more papers by this authorEdythe Wiggs
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Search for more papers by this authorKareem Zaghloul
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Search for more papers by this authorSara K. Inati
EEG Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Search for more papers by this authorWilliam D. Gaillard
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Center for Neuroscience, Children's National Hospital System, Washington, District of Columbia
Search for more papers by this authorCorresponding Author
William H. Theodore
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Correspondence
William H. Theodore, Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Email: [email protected]
Search for more papers by this authorSummary
Objective
We aimed to predict language deficits after epilepsy surgery. In addition to evaluating surgical factors examined previously, we determined the impact of the extent of functional magnetic resonance imaging (fMRI) activation that was resected on naming ability.
Method
Thirty-five adults (mean age 37.5 ± 10.9 years, 13 male) with temporal lobe epilepsy completed a preoperative fMRI auditory description decision task, which reliably activates frontal and temporal language networks. Patients underwent temporal lobe resections (20 left resection). The Boston Naming Test (BNT) was used to determine language functioning before and after surgery. Language dominance was determined for Broca and Wernicke area (WA) by calculating a laterality index following statistical parametric mapping processing. We used an innovative method to generate anatomic resection masks automatically from pre- and postoperative MRI tissue map comparison. This mask provided the following: (a) resection volume; (b) overlap between resection and preoperative activation; and (c) overlap between resection and WA. We examined postoperative language change predictors using stepwise linear regression. Predictors included parameters described above as well as age at seizure onset (ASO), preoperative BNT score, and resection side and its relationship to language dominance.
Results
Seven of 35 adults had significant naming decline (6 dominant-side resections). The final regression model predicted 38% of the naming score change variance (adjusted r2 = 0.28, P = 0.012). The percentage of top 10% fMRI activation resected (P = 0.017) was the most significant contributor. Other factors in the model included WA LI, ASO, volume of WA resected, and WA LI absolute value (extent of laterality).
Significance
Resection of fMRI activation during a word-definition decision task is an important factor for postoperative change in naming ability, along with other previously reported predictors. Currently, many centers establish language dominance using fMRI. Our results suggest that the amount of the top 10% of language fMRI activation in the intended resection area provides additional predictive power and should be considered when planning surgical resection.
DISCLOSURE
None of the authors have any conflict of interest to disclose. We have confirmed that we have read Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.
Supporting Information
| Filename | Description |
|---|---|
| epi14656-sup-0001-FigS1.docxWord document, 614.6 KB | |
| epi14656-sup-0002-FigS2.docxWord document, 456.2 KB | |
| epi14656-sup-0003-TableS1.docxWord document, 39.1 KB | |
| epi14656-sup-0004-TableS2.docxWord document, 37.5 KB | |
| epi14656-sup-0005-AppendixS1.docxWord document, 12 KB | |
| epi14656-sup-0006-MethodS1.docxWord document, 12.9 KB | |
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