Rehabilitation in children and adolescents undergoing stem cell transplantation: A pilot study focused on motor performance
Corresponding Author
Francesca Rossi
Rehabilitation Service, Public Health and Pediatric Sciences Department, A.O.U. Città della Salute e della Scienza - Regina Margherita Children's Hospital, Turin, Italy
Correspondence
Francesca Rossi, Rehabilitation Service, Public Health and Paediatric Sciences Department, A.O.U. Città della Salute e della Scienza - Regina Margherita Children's Hospital, Piazza Polonia 94, 10126, Turin, Italy.
Email: [email protected]
Search for more papers by this authorGiulia Zucchetti
Pediatric Oncohematology, Stem Cell Transplantation and Cell Therapy Division, A.O.U. Città della Salute e della Scienza - Regina Margherita Children's Hospital, Turin, Italy
Search for more papers by this authorMaria Esposito
School of Medicine, University of Turin, Turin, Italy
Search for more papers by this authorPaola Berchialla
Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
Search for more papers by this authorVeronica Sciannameo
Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padua, Italy
Search for more papers by this authorElena Vassallo
Pediatric Oncohematology, Stem Cell Transplantation and Cell Therapy Division, A.O.U. Città della Salute e della Scienza - Regina Margherita Children's Hospital, Turin, Italy
Search for more papers by this authorFrancesco Saglio
Pediatric Oncohematology, Stem Cell Transplantation and Cell Therapy Division, A.O.U. Città della Salute e della Scienza - Regina Margherita Children's Hospital, Turin, Italy
Search for more papers by this authorCarolina Chamorro Viña
Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada
Kids Cancer Care Foundation of Alberta, Calgary, Alberta, Canada
Search for more papers by this authorSilvia Scarrone
Pediatric Oncohematology, Stem Cell Transplantation and Cell Therapy Division, A.O.U. Città della Salute e della Scienza - Regina Margherita Children's Hospital, Turin, Italy
Search for more papers by this authorRoberta Vittorini
Section of Child and Adolescent Neuropsychiatry, Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy
Search for more papers by this authorFranca Fagioli
Pediatric Oncohematology, Stem Cell Transplantation and Cell Therapy Division, A.O.U. Città della Salute e della Scienza - Regina Margherita Children's Hospital, Turin, Italy
Search for more papers by this authorCorresponding Author
Francesca Rossi
Rehabilitation Service, Public Health and Pediatric Sciences Department, A.O.U. Città della Salute e della Scienza - Regina Margherita Children's Hospital, Turin, Italy
Correspondence
Francesca Rossi, Rehabilitation Service, Public Health and Paediatric Sciences Department, A.O.U. Città della Salute e della Scienza - Regina Margherita Children's Hospital, Piazza Polonia 94, 10126, Turin, Italy.
Email: [email protected]
Search for more papers by this authorGiulia Zucchetti
Pediatric Oncohematology, Stem Cell Transplantation and Cell Therapy Division, A.O.U. Città della Salute e della Scienza - Regina Margherita Children's Hospital, Turin, Italy
Search for more papers by this authorMaria Esposito
School of Medicine, University of Turin, Turin, Italy
Search for more papers by this authorPaola Berchialla
Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
Search for more papers by this authorVeronica Sciannameo
Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padua, Italy
Search for more papers by this authorElena Vassallo
Pediatric Oncohematology, Stem Cell Transplantation and Cell Therapy Division, A.O.U. Città della Salute e della Scienza - Regina Margherita Children's Hospital, Turin, Italy
Search for more papers by this authorFrancesco Saglio
Pediatric Oncohematology, Stem Cell Transplantation and Cell Therapy Division, A.O.U. Città della Salute e della Scienza - Regina Margherita Children's Hospital, Turin, Italy
Search for more papers by this authorCarolina Chamorro Viña
Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada
Kids Cancer Care Foundation of Alberta, Calgary, Alberta, Canada
Search for more papers by this authorSilvia Scarrone
Pediatric Oncohematology, Stem Cell Transplantation and Cell Therapy Division, A.O.U. Città della Salute e della Scienza - Regina Margherita Children's Hospital, Turin, Italy
Search for more papers by this authorRoberta Vittorini
Section of Child and Adolescent Neuropsychiatry, Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy
Search for more papers by this authorFranca Fagioli
Pediatric Oncohematology, Stem Cell Transplantation and Cell Therapy Division, A.O.U. Città della Salute e della Scienza - Regina Margherita Children's Hospital, Turin, Italy
Search for more papers by this authorFrancesca Rossi and Giulia Zucchetti contributed equally to this work.
Funding information:
All authors declare to having not received any funding support for this work.
Abstract
Objectives
The aim of this pilot trial is evaluating the preliminary effectiveness of two in-hospital interventions in the maintenance of motor performance in children/adolescents undergoing hematopoietic stem cell transplantation (HSCT). Secondary objectives investigated the interventions' feasibility, impact on fatigue and to what degree the subjects' maintained their ankle dorsiflexion range of movement (ROM), functional mobility, muscle strength and flexibility.
Methods
This trial included 5- to 18-year-old participants, affected by oncological and non-oncological diseases during hospitalisation for autologous/allogenic HSCT. The subjects were assigned to an exercise group (EG), or a counselling group based on a cluster model based on inpatient timeframe. The EG subjects performed strengthening, stretching and aerobic exercises for 30 min/5 days a week. Both groups followed rehabilitation counselling indications (RCI), 7 days a week.
Results
Forty-nine participants were enrolled (median age = 12.9 years) (EG n = 36). In both groups the participants maintained their baseline motor performance and ankle ROM, and the children/adolescents and parents reduced their levels of fatigue. However, the interventions were not effective in maintaining strength.
Conclusion
In maintaining the subjects' motor performance, the RCI results are significant because they pave the way for the application in clinical practice contexts where there are poor rehabilitation resources. Clinical Trials registration NCT03842735.
CONFLICT OF INTEREST
All authors declare no conflicts of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
| Filename | Description |
|---|---|
| ecc13711-sup-0001-Table S1 -LS_EJCC_ok.docxWord 2007 document , 12.7 KB |
Table S1: recruitment periods |
| ecc13711-sup-0002-Table S2 -FR_EJCC_ok.docWord document, 39 KB |
Table S2: outcome measure details |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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