Cancer survivors exhibit a different relationship between muscle strength and health-related quality of life/fatigue compared to healthy subjects
Corresponding Author
S. Morishita PhD
Physical Therapist, Associate Professor
Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan
Correspondence
Shinichiro Morishita, Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan.
Email: [email protected]
Search for more papers by this authorA. Tsubaki PhD
Physical Therapist, Associate Professor
Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan
Search for more papers by this authorJ.B. Fu MD
Associate Professor
Department of Palliative, Rehabilitation and Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorY. Mitobe BSc
Registerd Nurse, Assistant Professor
Department of Nursing, Niigata University of Health and Welfare, Niigata, Japan
Search for more papers by this authorH. Onishi PhD
Physical Therapist, Professor
Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan
Search for more papers by this authorT. Tsuji PhD, MD
Associate Professor
Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, Japan
Search for more papers by this authorCorresponding Author
S. Morishita PhD
Physical Therapist, Associate Professor
Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan
Correspondence
Shinichiro Morishita, Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan.
Email: [email protected]
Search for more papers by this authorA. Tsubaki PhD
Physical Therapist, Associate Professor
Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan
Search for more papers by this authorJ.B. Fu MD
Associate Professor
Department of Palliative, Rehabilitation and Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorY. Mitobe BSc
Registerd Nurse, Assistant Professor
Department of Nursing, Niigata University of Health and Welfare, Niigata, Japan
Search for more papers by this authorH. Onishi PhD
Physical Therapist, Professor
Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan
Search for more papers by this authorT. Tsuji PhD, MD
Associate Professor
Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, Japan
Search for more papers by this authorFunding information
This study was partly supported by a Grant-in-Aid for Niigata University of Health and Welfare as well as the M.D. Anderson Cancer Center support grant CA 016672.
Abstract
We investigated the difference in relationship between muscle strength and quality of life (QOL)/fatigue in long-term cancer survivors and healthy subjects. Thirty-six cancer survivors and 29 healthy subjects were assessed for body composition and bone status at the calcaneus using the Osteo Sono Assessment Index. Muscle strength was evaluated via handgrip and knee extensor strength. Health-related QOL was assessed using the Medical Outcome Study 36-item Short-Form Health Survey. Fatigue was measured using the brief fatigue inventory. Cancer survivors exhibited lower QOL scores in the physical functioning, physical role function, bodily pain and general health domains (p < .05). Grip and knee extension muscle strength in cancer survivors was positively correlated with the physical function and bodily pain of QOL (p < .05). The usual fatigue subscale score was only significantly higher in cancer survivors than in healthy subjects (p < .05). However, there were no correlations between muscle strength and fatigue in cancer survivors. Our results showed that muscle strength was an important factor for improving QOL in cancer survivors. We believe that the findings of this study will be relevant in the context of planning rehabilitation for cancer survivors.
CONFLICT OF INTEREST
The authors declare that they have no conflict of interests.
REFERENCES
- Alaloul, F., Brockopp, D. Y., Andrykowski, M. A., Hall, L. A., & Al Nusairat, T. S. (2015). Quality of life in Arab Muslim cancer survivors following hematopoietic stem cell transplantation: Comparison with matched healthy group. Supportive Care in Cancer, 23, 2157–2164.
- Berger, A. M., Gerber, L. H., & Mayer, D. K. (2012). Cancer-related fatigue: Implications for breast cancer survivors. Cancer, 118, 2261–2269.
- Bower, J. E. (2014). Cancer-related fatigue–mechanisms, risk factors, and treatments. Nature Reviews Clinical Oncology, 11, 597–609.
- Chien, M. Y., Huang, T. Y., & Wu, Y. T. (2008). Prevalence of sarcopenia estimated using a bioelectrical impedance analysis prediction equation in community-dwelling elderly people in Taiwan. Journal of the American Geriatrics Society, 56, 1710–1715.
- De Lima, F. D., Bottaro, M., De Oliveira Valeriano, R., Cruz, L., Battaglini, C. L., Vieira, C. A., & De Oliveira, R. J. (2017). Cancer-related fatigue and muscle quality in Hodgkin's lymphoma survivors. Integrative Cancer Therapies. https://doi.org/10.1177/1534735417712009
- Fong, S. S., Ng, S. S., Luk, W. S., Chung, J. W., Chung, L. M., Tsang, W. W., & Chow, L. P. (2013). Shoulder mobility, muscular strength, and quality of life in breast cancer survivors with and without Tai Chi Qigong training. Evidence-Based Complementary and Alternative Medicine, 2013, 787169.
- Fukuhara, S., Bito, S., Green, J., Hsiao, A., & Kurokawa, K. (1998). Translation, adaptation, and validation of the SF-36 Health Survey for use in Japan. Journal of Clinical Epidemiology, 51, 1037–1044.
- Fukuhara, S., & Suzukamo, Y. (2004). Manual of SF-36v2 Japanese Version. Kyoto, Japan: Institute for Health Outcomes & Process Evaluation Research.
- Fukuhara, S., Ware, J. J., Kosinski, M., Wada, S., & Gandek, B. (1998). Psychometric and clinical tests of validity of the Japanese SF-36 Health Survey. Journal of Clinical Epidemiology, 51, 1045–1053.
- George, S. M., Mctiernan, A., Villaseñor, A., Alfano, C. M., Irwin, M. L., Neuhouser, M. L., … Ballard-Barbash, R. (2013). Disentangling the body weight-bone mineral density association among breast cancer survivors: An examination of the independent roles of lean mass and fat mass. BMC Cancer, 13, 497.
- Gomes, P. R., Freitas Junior, I. F., Da Silva, C. B., Gomes, I. C., Rocha, A. P., Salgado, A. S., & Do Carmo, E. M. (2014). Short-term changes in handgrip strength, body composition, and lymphedema induced by breast cancer surgery. Revista Brasileira de Ginecologia e Obstetrícia, 36, 244–250.
- Hayashi, K., Kako, M., Suzuki, K., Hattori, K., Fukuyasu, S., Sato, K., … Nishida, Y. (2017). Associations among pain catastrophizing, muscle strength, and physical performance after total knee and hip arthroplasty. World Journal of Orthopedics, 8, 336–341.
- Hofman, M., Ryan, J. L., Figueroa-Moseley, C. D., Jean-Pierre, P., & Morrow, G. R. (2007). Cancer-related fatigue: The scale of the problem. Oncologist, 12(Suppl. 1), 4–10.
- Huang, C., Momma, H., Niu, K., Chujo, M., Otomo, A., Cui, Y., & Nagatomi, R. (2016). High serum adiponectin levels predict incident falls among middle-aged and older adults: A prospective cohort study. Age and Ageing, 45, 366–371.
- Janssen, I., Heymsfield, S. B., Baumgartner, R. N., & Ross, R. (2000). Estimation of skeletal muscle mass by bioelectrical impedance analysis. Journal of Applied Physiology, 89, 465–471.
- Katanoda, K., Matsuda, T., Matsuda, A., Shibata, A., Nishino, Y., Fujita, M., … Nishimoto, H. (2013). An updated report of the trends in cancer incidence and mortality in Japan. Japanese Journal of Clinical Oncology, 43, 492–507.
- Katoh, M., & Yamasaki, H. (2009a). Comparison of reliability of isometric leg muscle strength measurements made using a hand-held dynamometer with and without a restraining belt. Journal of Physical Therapy Science, 21, 37–42.
- Katoh, M., & Yamasaki, H. (2009b). Test-retest reliability of isometric leg muscle strength measurements made using a hand-held dynamometer restrained by a belt: Comparisons during and between sessions. Journal of Physical Therapy Science, 21, 239–243.
- Kenzik, K. M., Morey, M. C., Cohen, H. J., Sloane, R., & Demark-Wahnefried, W. (2015). Symptoms, weight loss, and physical function in a lifestyle intervention study of older cancer survivors. Journal of Geriatric Oncology, 6, 424–432.
- Kerleau, C., Guizard, A. V., Daubisse-Marliac, L., Heutte, N., Mercier, M., Grosclaude, P., … Cowppli-Bony, A. (2016). Long-term quality of life among localised prostate cancer survivors: QALIPRO population-based study. European Journal of Cancer, 63, 143–153.
- Kiecolt-Glaser, J. K., Bennett, J. M., Andridge, R., Peng, J., Shapiro, C. L., Malarkey, W. B., … Glaser, R. (2014). Yoga's impact on inflammation, mood, and fatigue in breast cancer survivors: A randomized controlled trial. Journal of Clinical Oncology, 32, 1040–1049.
- Malhotra, R., Ang, S., Allen, J. C., Tan, N. C., Østbye, T., Saito, Y., & Chan, A. (2016). Normative values of hand grip strength for elderly Singaporeans aged 60 to 89 years: A cross-sectional study. Journal of the American Medical Directors Association, 17, 864.e861-867.
- Maly, R. C., Liu, Y., Liang, L. J., & Ganz, P. A. (2015). Quality of life over 5 years after a breast cancer diagnosis among low-income women: Effects of race/ethnicity and patient-physician communication. Cancer, 121, 916–926.
- Mendoza, T. R., Wang, X. S., Cleeland, C. S., Morrissey, M., Johnson, B. A., Wendt, J. K., & Huber, S. L. (1999). The rapid assessment of fatigue severity in cancer patients: Use of the Brief Fatigue Inventory. Cancer, 85, 1186–1196.
10.1002/(SICI)1097-0142(19990301)85:5<1186::AID-CNCR24>3.0.CO;2-N CAS PubMed Web of Science® Google Scholar
- Miller, K. D., Siegel, R. L., Lin, C. C., Mariotto, A. B., Kramer, J. L., Rowland, J. H., … Jemal, A. (2016). Cancer treatment and survivorship statistics, 2016. CA: A Cancer Journal for Clinicians, 66, 271–289.
- Morishita, S., Kaida, K., Yamauchi, S., Wakasugi, T., Yoshihara, S., Taniguchi, K., … Domen, K. (2013). Gender differences in health-related quality of life, physical function and psychological status among patients in the early phase following allogeneic haematopoietic stem cell transplantation. Psychooncology, 22, 1159–1166.
- Öberg, A., Genberg, M., Malinovschi, A., Hedenström, H., & Frisk, P. (2017). Exercise capacity in young adults after hematopoietic cell transplantation in childhood. American Journal of Transplantation, 18, 417–423.
- Okuyama, T., Wang, X. S., Akechi, T., Mendoza, T. R., Hosaka, T., Cleeland, C. S., & Uchitomi, Y. (2003). Validation study of the Japanese version of the brief fatigue inventory. Journal of Pain and Symptom Management, 25, 106–117.
- Sánchez-Jiménez, A., Cantarero-Villanueva, I., Delgado-García, G., Molina-Barea, R., Fernández-Lao, C., Galiano-Castillo, N., & Arroyo-Morales, M. (2015). Physical impairments and quality of life of colorectal cancer survivors: A case-control study. European Journal of Cancer Care (England), 24, 642–649.
- Shneerson, C., Taskila, T., Gale, N., Greenfield, S., & Chen, Y. F. (2013). The effect of complementary and alternative medicine on the quality of life of cancer survivors: A systematic review and meta-analyses. Complementary Therapies in Medicine, 21, 417–429.
- Siegel, R. L., Fedewa, S. A., Miller, K. D., Goding-Sauer, A., Pinheiro, P. S., Martinez-Tyson, D., & Jemal, A. (2015). Cancer statistics for Hispanics/Latinos, 2015. CA: A Cancer Journal for Clinicians, 65, 457–480.
- Smith, A. W., Bellizzi, K. M., Keegan, T. H., Zebrack, B., Chen, V. W., Neale, A. V., … Lynch, C. F. (2013). Health-related quality of life of adolescent and young adult patients with cancer in the United States: The Adolescent and Young Adult Health Outcomes and Patient Experience study. Journal of Clinical Oncology, 31, 2136–2145.
- Tsuda-Futami, E., Hans, D., Njeh, C. F., Fuerst, T., Fan, B., Li, J., … Genant, H. K. (1999). An evaluation of a new gel-coupled ultrasound device for the quantitative assessment of bone. British Journal of Radiology, 72, 691–700.
- Usa, H., Matsumura, M., Ichikawa, K., & Takei, H. (2017). A maximum muscle strength prediction formula using theoretical grade 3 muscle strength value in Daniels et al.'s manual muscle test, in consideration of age: An investigation of hip and knee joint flexion and extension. Rehabilitation Research and Practice. https://doi.org/10.1155/2017/3985283
- Villaseñor, A., Ballard-Barbash, R., Baumgartner, K., Baumgartner, R., Bernstein, L., Mctiernan, A., & Neuhouser, M. L. (2012). Prevalence and prognostic effect of sarcopenia in breast cancer survivors: The HEAL Study. Journal of Cancer Survivorship, 6, 398–406.
- Von Ah, D. M., Russell, K. M., Carpenter, J., Monahan, P. O., Qianqian, Z., Tallman, E., … Champion, V. L. (2012). Health-related quality of life of African American breast cancer survivors compared with healthy African American women. Cancer Nursing, 35, 337–346.
- Winters-Stone, K. M., Bennett, J. A., Nail, L., & Schwartz, A. (2008). Strength, physical activity, and age predict fatigue in older breast cancer survivors. Oncology Nursing Forum, 35, 815–821.
- Yee, J., Davis, G. M., Beith, J. M., Wilcken, N., Currow, D., Emery, J., … Kilbreath, S. L. (2014). Physical activity and fitness in women with metastatic breast cancer. Journal of Cancer Survivorship, 8, 647–656.
- Yoo, Y. S., & Cho, O. H. (2014). Relationship between quality of life and nurse-led bedside symptom evaluations in patients with chemotherapy-induced peripheral neuropathy. Asian Nursing Research (Korean Soc Nurs Sci), 8, 36–41.
- Yu, R., Ong, S., Cheung, O., Leung, J., & Woo, J. (2017). Reference values of grip strength, prevalence of low grip strength, and factors affecting grip strength values in Chinese adults. Journal of the American Medical Directors Association, 18, 551.e559–551.e516.
