Histopathological aspects and differential diagnosis of CD8 positive lymphomatoid papulosis
Márta Marschalkó
Department of Dermatology Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
Search for more papers by this authorNóra Gyöngyösi
Department of Dermatology Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
Search for more papers by this authorJudit Noll
Department of Dermatology, Heim Pál Childrens Hospital, Budapest, Hungary
Search for more papers by this authorZsuzsanna Károlyi
Department of Dermatology, Semmelweis Hospital, Miskolc, Hungary
Search for more papers by this authorNorbert Wikonkál
Department of Dermatology Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
Search for more papers by this authorJudit Hársing
Department of Dermatology Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
Search for more papers by this authorEnikő Kuroli
Department of Dermatology Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
Search for more papers by this authorJudit Csomor
1st Department of Pathology and Experimental Cancer Research Institute, Semmelweis University, Budapest, Hungary
Search for more papers by this authorAndrás Matolcsy
1st Department of Pathology and Experimental Cancer Research Institute, Semmelweis University, Budapest, Hungary
Search for more papers by this authorKárpáti Sarolta
Department of Dermatology Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
Search for more papers by this authorCorresponding Author
Ágota Szepesi
1st Department of Pathology and Experimental Cancer Research Institute, Semmelweis University, Budapest, Hungary
Ágota Szepesi
1st Department of Pathology and Experimental Cancer Research Institute, Semmelweis University, Üllői str. 26. Budapest, 1085 Hungary
Tel: +36 1 215 7300
Fax: +36 1 317 5097
e-mail: [email protected]
Search for more papers by this authorMárta Marschalkó
Department of Dermatology Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
Search for more papers by this authorNóra Gyöngyösi
Department of Dermatology Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
Search for more papers by this authorJudit Noll
Department of Dermatology, Heim Pál Childrens Hospital, Budapest, Hungary
Search for more papers by this authorZsuzsanna Károlyi
Department of Dermatology, Semmelweis Hospital, Miskolc, Hungary
Search for more papers by this authorNorbert Wikonkál
Department of Dermatology Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
Search for more papers by this authorJudit Hársing
Department of Dermatology Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
Search for more papers by this authorEnikő Kuroli
Department of Dermatology Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
Search for more papers by this authorJudit Csomor
1st Department of Pathology and Experimental Cancer Research Institute, Semmelweis University, Budapest, Hungary
Search for more papers by this authorAndrás Matolcsy
1st Department of Pathology and Experimental Cancer Research Institute, Semmelweis University, Budapest, Hungary
Search for more papers by this authorKárpáti Sarolta
Department of Dermatology Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
Search for more papers by this authorCorresponding Author
Ágota Szepesi
1st Department of Pathology and Experimental Cancer Research Institute, Semmelweis University, Budapest, Hungary
Ágota Szepesi
1st Department of Pathology and Experimental Cancer Research Institute, Semmelweis University, Üllői str. 26. Budapest, 1085 Hungary
Tel: +36 1 215 7300
Fax: +36 1 317 5097
e-mail: [email protected]
Search for more papers by this authorAbstract
Lymphomatoid papulosis (LyP) belongs to CD30+ lymphoproliferative disorders with indolent clinical course. Classic histological subtypes, A, B and C are characterized by the CD4+ phenotype, while CD8+ variants, most commonly classified as type D, were reported in recent years. We present 14 cases of CD8+ LyP. In all patients, self-resolving or treatment-sensitive papules were observed. Of 14 cases 7 produced results with typical microscopic features of LyP type D mimicking primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma. The infiltration pattern in 4 of 14 cases were consistent with classic LyP type B, without CD30 expression in two cases, resembling mycosis fungoides (MF). The morphology of 2 of 14 cases shared a certain consistency with classic type A and C, lacking eosinophils and neutrophils. Extensive folliculotropism characteristic to type F was observed in 1 of 14 case. Significant MUM1 and PD1 expression were detected in 2 of 14 and 3 of 14 cases, respectively. We concluded that CD8+ LyP may present with different histopathological features compared with type D, similar to CD4+ LyP variants. Differential diagnoses include CD8+ papular MF, folliculotropic MF and anaplastic large cell lymphoma in addition to primary cutaneous aggressive epidermotropic T-cell lymphoma. We emphasise that rare CD8+ LyP cases may exist with CD30-negativity.
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