Evaluation of the first maxillary molar post-extraction socket as a model for dental implant osseointegration research
Zhibin Du
Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Qld, Australia
Search for more papers by this authorRyan S. B. Lee
School of Dentistry and Oral Health, Griffith University, Southport, Qld, Australia
Search for more papers by this authorStephen Hamlet
School of Dentistry and Oral Health, Griffith University, Southport, Qld, Australia
Search for more papers by this authorNghiem Doan
Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Qld, Australia
Search for more papers by this authorCorresponding Author
Saso Ivanovski
School of Dentistry and Oral Health, Griffith University, Southport, Qld, Australia
Corresponding authors:
Professor Yin Xiao
Institute of Health and Biomedical Innovation
Queensland University of Technology
Kelvin Grove Campus
Brisbane
Qld 4059
Australia
Tel.: +61 7 31386240
Fax: +61 7 31386030
e-mail: [email protected]
and
Professor Saso Ivanovski
Griffith University
Gold Coast Campus
Griffith Centre, G40_7.81
Parkland Drive
Southport
QLD 4222
Australia
Tel.: +61 7 56780741
Fax: +61 7 56780708
e-mail: [email protected]
Search for more papers by this authorCorresponding Author
Yin Xiao
Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Qld, Australia
Corresponding authors:
Professor Yin Xiao
Institute of Health and Biomedical Innovation
Queensland University of Technology
Kelvin Grove Campus
Brisbane
Qld 4059
Australia
Tel.: +61 7 31386240
Fax: +61 7 31386030
e-mail: [email protected]
and
Professor Saso Ivanovski
Griffith University
Gold Coast Campus
Griffith Centre, G40_7.81
Parkland Drive
Southport
QLD 4222
Australia
Tel.: +61 7 56780741
Fax: +61 7 56780708
e-mail: [email protected]
Search for more papers by this authorZhibin Du
Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Qld, Australia
Search for more papers by this authorRyan S. B. Lee
School of Dentistry and Oral Health, Griffith University, Southport, Qld, Australia
Search for more papers by this authorStephen Hamlet
School of Dentistry and Oral Health, Griffith University, Southport, Qld, Australia
Search for more papers by this authorNghiem Doan
Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Qld, Australia
Search for more papers by this authorCorresponding Author
Saso Ivanovski
School of Dentistry and Oral Health, Griffith University, Southport, Qld, Australia
Corresponding authors:
Professor Yin Xiao
Institute of Health and Biomedical Innovation
Queensland University of Technology
Kelvin Grove Campus
Brisbane
Qld 4059
Australia
Tel.: +61 7 31386240
Fax: +61 7 31386030
e-mail: [email protected]
and
Professor Saso Ivanovski
Griffith University
Gold Coast Campus
Griffith Centre, G40_7.81
Parkland Drive
Southport
QLD 4222
Australia
Tel.: +61 7 56780741
Fax: +61 7 56780708
e-mail: [email protected]
Search for more papers by this authorCorresponding Author
Yin Xiao
Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Qld, Australia
Corresponding authors:
Professor Yin Xiao
Institute of Health and Biomedical Innovation
Queensland University of Technology
Kelvin Grove Campus
Brisbane
Qld 4059
Australia
Tel.: +61 7 31386240
Fax: +61 7 31386030
e-mail: [email protected]
and
Professor Saso Ivanovski
Griffith University
Gold Coast Campus
Griffith Centre, G40_7.81
Parkland Drive
Southport
QLD 4222
Australia
Tel.: +61 7 56780741
Fax: +61 7 56780708
e-mail: [email protected]
Search for more papers by this authorAbstract
Objectives
Published information regarding the use of rat jawbones for dental implant osseointegration research is limited and often inconsistent. This study assessed the suitability and feasibility of placing dental implants into the rat maxilla and to establish parameters to be used for dental implant research using this model.
Materials and methods
Forty-two customized titanium implants (2 × 3 mm) were placed bilaterally in the maxillary first molar area of 21 Sprague–Dawley rats. Every animal received two implants. The animals were subsequently sacrificed at days 3, 7, 14, 28 and 56 post-surgery. Resin-embedded sections of the implant and surrounding maxilla were prepared for histological and histomorphometric analyses.
Results
The mesial root of the first molar in the rat maxilla was the optimal site to place the implant. Although the most apical 2–3 threads of the implant penetrated into the sinus cavity, 2 mm of the remaining implant was embedded in the bone. New bone formation at day 7 around the implant increased further at day 14, as measured by the percentage of bone-to-implant contact (%BIC) and new bone area (%BA) in the implant thread chambers (55.1 ± 8.9% and 63.7 ± 7.7%, respectively). There was a further significant increase between day 14 and 28 (P < 0.05), however, no significant differences were found between day 28 and 56 in either %BIC or %BA.
Conclusions
The mesial root socket of the first molar in the rat maxilla is a useful model for dental implant research. Osseointegration following implant placement as measured by BIC plateaued after 28 days. The recommended implant dimensions are 1.5 mm in diameter and 2 mm in length.
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