Clinical and Histomorphometric Evaluation of Fresh Frozen Bone Allograft in Sinus Lift Surgery
Corresponding Author
Tatiana Regina Ramos Nantes de Castilho DDS, MSc
Implantologist
Implantology Specialization Course, Fundação da Faculdade de Odontologia, School of Dentistry, University of São Paulo, São Paulo, Brazil
Corresponding Author: Tatiana R.R. Nantes de Castilho, FFO–FOUSP, Av. Prof. Lineu Prestes, 2227 Cidade Universitária, 05508-000 São Paulo, SP Brazil; e-mail: [email protected]Search for more papers by this authorPedro Tortamano DDS, PhD
assistant professor
Department of Prosthodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil
Search for more papers by this authorJuliana Marotti DDS, PhD
Dental Assistant and Researcher
Department of Prosthodontics and Biomaterials, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
Search for more papers by this authorJosé Carlos Silva de Andrade Jr DDS
Implantologist
Implantology Specialization Course, Fundação da Faculdade de Odontologia, School of Dentistry, University of São Paulo, São Paulo, Brazil
Search for more papers by this authorIsrael Chilvarquer DDS, PhD
associate professor
Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil
Search for more papers by this authorMichel Eli Lipiec Ximenez DDS
professor
Radiology Specialization Course, Associação Paulista dos Cirurgiões Dentistas—Jardim Paulista, São Paulo, Brazil
Search for more papers by this authorMaria Teresa de Seixas Alves MD, PhD
full professor
Department of Pathology, Federal University of São Paulo, São Paulo, Brazil
Search for more papers by this authorCorresponding Author
Tatiana Regina Ramos Nantes de Castilho DDS, MSc
Implantologist
Implantology Specialization Course, Fundação da Faculdade de Odontologia, School of Dentistry, University of São Paulo, São Paulo, Brazil
Corresponding Author: Tatiana R.R. Nantes de Castilho, FFO–FOUSP, Av. Prof. Lineu Prestes, 2227 Cidade Universitária, 05508-000 São Paulo, SP Brazil; e-mail: [email protected]Search for more papers by this authorPedro Tortamano DDS, PhD
assistant professor
Department of Prosthodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil
Search for more papers by this authorJuliana Marotti DDS, PhD
Dental Assistant and Researcher
Department of Prosthodontics and Biomaterials, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
Search for more papers by this authorJosé Carlos Silva de Andrade Jr DDS
Implantologist
Implantology Specialization Course, Fundação da Faculdade de Odontologia, School of Dentistry, University of São Paulo, São Paulo, Brazil
Search for more papers by this authorIsrael Chilvarquer DDS, PhD
associate professor
Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil
Search for more papers by this authorMichel Eli Lipiec Ximenez DDS
professor
Radiology Specialization Course, Associação Paulista dos Cirurgiões Dentistas—Jardim Paulista, São Paulo, Brazil
Search for more papers by this authorMaria Teresa de Seixas Alves MD, PhD
full professor
Department of Pathology, Federal University of São Paulo, São Paulo, Brazil
Search for more papers by this authorAbstract
Purpose
The aim of this prospective clinical study was to evaluate the clinical and histomorphometric data of newly formed bone tissue from fresh frozen human allograft in sinus lift surgery.
Patients and Methods
Thirty-three sinus lift procedures were performed in 20 patients, divided into two groups. The control group (n = 8) received autogenous bone from the mandibular ramus, and the experimental group (n = 12) received fresh frozen bone (FFB) allograft in chips. After 6 months, 52 implants were placed and 50 biopsies were collected for histomorphometric analysis. Cone beam computed tomography scans were performed at preoperative, immediate postoperative, and delayed postoperative time intervals to assess the degree of graft volume loss.
Results
There was no statistically significant difference between groups as regards degree of graft volume loss (p = .983), total bone area (p = .191), remaining particles (p = .348), and proportion of active osteoblasts (p = .867). There was a statistically significant difference in the vitality rate between the groups (p = .043). In both groups, all implants were clinically osseointegrated after 4 months.
Conclusion
FFB allograft was shown to be a feasible substitute for autogenous bone graft in sinus lift surgery.
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