ORIGINAL ARTICLE

Contrast-enhanced 3D-T2-weighted SPACE sequence for MRI detection and localization of adrenocorticotropin (ACTH)-secreting pituitary microadenomas

Yue Wu

Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

Yixin Cai

Department of Neurosurgery, National Center for Neurological Disorders (NCND), Shanghai Pituitary Tumor Center, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Wenting Rui,

Wenting Rui

Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Ying Tang,

Ying Tang

Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Zhong Yang,

Zhong Yang

Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Min He,

Min He

Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Hongying Ye,

Hongying Ye

Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Yongfei Wang,

Yongfei Wang

Department of Neurosurgery, National Center for Neurological Disorders (NCND), Shanghai Pituitary Tumor Center, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Yao Zhao,

Yao Zhao

Department of Neurosurgery, National Center for Neurological Disorders (NCND), Shanghai Pituitary Tumor Center, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Zengyi Ma,

Corresponding Author

Zengyi Ma

[email protected]

Department of Neurosurgery, National Center for Neurological Disorders (NCND), Shanghai Pituitary Tumor Center, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

Correspondence

Zengyi Ma, Department of Neurosurgery, National Center for Neurological Disorders (NCND), Shanghai Pituitary Tumor Center, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China. Email: [email protected]

Zhenwei Yao, Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

Email: [email protected]

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Zhenwei Yao,

Corresponding Author

Zhenwei Yao

[email protected]

orcid.org/0000-0002-5681-4308

Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

Correspondence

Zhenwei Yao, Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

Email: [email protected]

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Yue Wu,

Yue Wu

Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Yixin Cai,

Yixin Cai

Department of Neurosurgery, National Center for Neurological Disorders (NCND), Shanghai Pituitary Tumor Center, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Wenting Rui,

Wenting Rui

Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Ying Tang,

Ying Tang

Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Zhong Yang,

Zhong Yang

Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Min He,

Min He

Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Hongying Ye,

Hongying Ye

Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Yongfei Wang,

Yongfei Wang

Department of Neurosurgery, National Center for Neurological Disorders (NCND), Shanghai Pituitary Tumor Center, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Yao Zhao,

Yao Zhao

Department of Neurosurgery, National Center for Neurological Disorders (NCND), Shanghai Pituitary Tumor Center, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

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Zengyi Ma,

Corresponding Author

Zengyi Ma

[email protected]

Department of Neurosurgery, National Center for Neurological Disorders (NCND), Shanghai Pituitary Tumor Center, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

Correspondence

Zhenwei Yao, Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

Email: [email protected]

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Zhenwei Yao,

Corresponding Author

Zhenwei Yao

[email protected]

orcid.org/0000-0002-5681-4308

Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

Correspondence

Zhenwei Yao, Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

Email: [email protected]

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First published: 29 July 2021

https://doi.org/10.1111/cen.14574

Citations: 7

Yue Wu and Yixin Cai are considered joint first author.

Zhenwei Yao and Zengyi Ma are considered joint senior author.

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Abstract

Objective

Cushing disease is a potentially fatal endocrine disorder caused by adrenocorticotropin (ACTH)-secreting microadenomas in the pituitary gland. Accurate detection and localization of the adenomas is the key to clinical treatment. This study analysed the value of contrast-enhanced Sampling Perfection with Application-optimized Contrasts using different flip angle Evolutions (SPACE) sequence in magnetic resonance imaging (MRI) assessment of ACTH-secreting pituitary microadenomas.

Design and Patients

We carried out a retrospective study in which 45 patients with ACTH-secreting pituitary microadenomas were enrolled. Dynamic contrast-enhanced (DCE) coronal T1-SE sequence was performed. A contrast-enhanced coronal SPACE sequence was added immediately after DCE MRI finished. Two independent observers assessed the tumour existence and location, then the results were compared with surgical findings.

Results

Twenty-four lesions (53.3%) were detected by the DCE T1-SE sequence alone, while 35 lesions (80.0%) were detected with the addition of contrast-enhanced SPACE sequence. The sensitivity (58.5% vs. 85.3%; p < .05) and best diagnostic accuracy (62.0% vs. 84.4%; p < .05) were significantly better for addition with SPACE sequence than DCE-SE images alone in detection of ACTH-secreting pituitary microadenomas. For lesions <5 mm, the detected numbers were 4 (16.6%) versus 10 (27.8%) by DCE T1-SE sequence and combined DCE T1-SE with SPACE sequence.

Conclusions

A combination of contrast-enhanced SPACE with DCE T1-SE sequence could improve the detection of ACTH-secreting pituitary microadenomas. Contrast-enhanced SPACE sequence could be a supplementary sequence for imaging of ACTH-secreting pituitary adenomas when T1-SE sequence provides negative or equivocal findings.

CONFLICT OF INTERESTS

The authors declare that there are no conflict of interests.

Open Research

DATA AVAILABILITY STATEMENT

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Volume96, Issue4

April 2022

Pages 578-588

Contrast-enhanced 3D-T2-weighted SPACE sequence for MRI detection and localization of adrenocorticotropin (ACTH)-secreting pituitary microadenomas

Abstract

Objective

Design and Patients

Results

Conclusions

CONFLICT OF INTERESTS

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

Information

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Contrast-enhanced 3D-T2-weighted SPACE sequence for MRI detection and localization of adrenocorticotropin (ACTH)-secreting pituitary microadenomas

Abstract

Objective

Design and Patients

Results

Conclusions

CONFLICT OF INTERESTS

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

Related

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