Clinical Question

Breast cancer risk in MEN1 – a cancer genetics perspective

Corresponding Author

Paul Brennan

Northern Genetics Service, Newcastle Upon Tyne, UK

Correspondence: Paul Brennan, Northern Genetics Service, Newcastle Upon Tyne, UK. Tel.: +44 191 2418600; E-mail: [email protected]Search for more papers by this author

Paul Brennan,

Corresponding Author

Paul Brennan

Northern Genetics Service, Newcastle Upon Tyne, UK

Correspondence: Paul Brennan, Northern Genetics Service, Newcastle Upon Tyne, UK. Tel.: +44 191 2418600; E-mail: [email protected]Search for more papers by this author

First published: 03 October 2014

https://doi.org/10.1111/cen.12614

Citations: 10

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Summary

The tumour spectrum associated with multiple endocrine neoplasia type 1 (MEN1) has been known for many years. New data suggest that females with MEN1 may face an additional, hitherto unrecognized, risk of early-onset breast cancer. The menin protein is certainly known to have a role in regulating oestrogen receptor activity; but how robust are the data linking MEN1 to breast cancer? This article examines the published data from the viewpoint of a cancer geneticist and considers whether there really is a justifiable indication for enhanced breast surveillance in women with MEN1.

References

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Volume82, Issue3

March 2015

Pages 327-229

Breast cancer risk in MEN1 – a cancer genetics perspective

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Breast cancer risk in MEN1 – a cancer genetics perspective

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