Volume 171, Issue 1 pp. 116-119

Short Report

Survival of childhood acute lymphoid leukaemia in Yorkshire by clinical trial era, 1990–2011

Marlous van Laar,

Marlous van Laar

Division of Epidemiology and Biostatistics, School of Medicine, University of Leeds, Leeds, UK

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Sally E. Kinsey,

Sally E. Kinsey

Regional Department of Paediatric Oncology and Haematology, Leeds, UK

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Richard G. Feltbower,

Corresponding Author

Richard G. Feltbower

Division of Epidemiology and Biostatistics, School of Medicine, University of Leeds, Leeds, UK

Correspondence : Dr Richard Feltbower, Division of Epidemiology and Biostatistics, School of Medicine, University of Leeds, Worsley Building, Clarendon Way, Leeds, LS2 9JT, UK.

E-mail: [email protected]

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Marlous van Laar,

Marlous van Laar

Division of Epidemiology and Biostatistics, School of Medicine, University of Leeds, Leeds, UK

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Sally E. Kinsey,

Sally E. Kinsey

Regional Department of Paediatric Oncology and Haematology, Leeds, UK

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Richard G. Feltbower,

Corresponding Author

Richard G. Feltbower

Division of Epidemiology and Biostatistics, School of Medicine, University of Leeds, Leeds, UK

Correspondence : Dr Richard Feltbower, Division of Epidemiology and Biostatistics, School of Medicine, University of Leeds, Worsley Building, Clarendon Way, Leeds, LS2 9JT, UK.

E-mail: [email protected]

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First published: 04 June 2015

https://doi.org/10.1111/bjh.13524

Citations: 2

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Summary

Gender-specific differences in survival by clinical trial era in Yorkshire were assessed for children with acute lymphoid leukaemia (ALL) enrolled onto UKALLXI, ALL97/99 or UKALL2003 (n = 630; 1990–2011). For males, there was a non-significant improvement in survival for ALL97/99 [hazard ratio (HR) = 0·77; 95% confidence interval (CI) 0·43–1·42) and a significant improvement for UKALL2003 (HR = 0·50; 95%CI 0·25–0·99) compared to UKALLXI. For females, survival was significantly improved for ALL97/99 (HR = 0·33; 95%CI 0·14–0·78), and non-significantly improved for UKALL2003 (HR = 0·51; 95%CI 0·25–1·08) compared to UKALLXI. Modest overall survival improvements masked clinically important gender-specific changes over time by trial era, requiring confirmation in larger population-based studies.

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Volume171, Issue1

October 2015

Pages 116-119

Survival of childhood acute lymphoid leukaemia in Yorkshire by clinical trial era, 1990–2011

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Survival of childhood acute lymphoid leukaemia in Yorkshire by clinical trial era, 1990–2011

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