Prognostic effect of sarcopenia in patients undergoing laparoscopic rectal cancer resection
Abstract
Background
The importance of body composition, in particular skeletal muscle mass, as risk factor affecting survival of cancer patients has recently gained increasing attention. The relationship between sarcopenia and oncological outcomes has become a topic of research in particular in patients with gastrointestinal cancer. However, there are few studies addressing this issue in colorectal cancer, and even less specifically focused on rectal cancer, in particular in Western countries. The aim of this study was to evaluate the prognostic relevance of preoperative skeletal mass index (SMI) on long-term outcomes in patients undergoing laparoscopic curative resection for rectal cancer.
Methods
SMI data and clinicopathological characteristics of rectal cancer patients in a 15-year period (June 2005–December 2020) were evaluated; patients with metastatic disease at surgery were excluded; overall and disease-free survival as well as recurrence were evaluated.
Results
Hundred and sixty-five patients were included in the study. Sarcopenia was identified in 30 (18%) patients. Multivariate analysis identified sarcopenia (HR = 3.28, CI = 1.33–8.11, P = 0.015), along with age (HR = 1.06, CI = 1.02–1.10, P = 0.002) and stage III (HR = 2.63, CI = 1.13–6.08, P < 0.03) as independent risk factors for overall survival.
Conclusion
Long-term results of rectal cancer patients undergoing curative resection are affected by their preoperative skeletal muscle status. Larger studies including comprehensive data on muscle strength along with SMI are awaited to confirm these results on both Eastern and Western rectal cancer patient populations before strategies to reverse muscle depletion can be extensively applied.
Conflict of interest
Giuseppe Portale, Matteo Zuin, Ylenia Camilla Spolverato, Patrizia Bartolotta, Dario Gregori, Carlo Rettore, Luca Cancian, Alberto Morabito, Teodoro Sava and Valentino Fiscon have no conflict of interest to disclose or financial ties to declare.
