LncRNA-regulated Infection and Inflammation Pathways Associated with Pregnancy Loss: Genome Wide Differential Expression of lncRNAs in Early Spontaneous Abortion
Hong Wang
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Chinese Alliance of Translational Medicine for Maternal and Children's Health, Shijiazhuang, China
These authors contributed equally to this work.Search for more papers by this authorQingying Cao
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Chinese Alliance of Translational Medicine for Maternal and Children's Health, Shijiazhuang, China
These authors contributed equally to this work.Search for more papers by this authorJun Ge
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Chinese Alliance of Translational Medicine for Maternal and Children's Health, Shijiazhuang, China
These authors contributed equally to this work.Search for more papers by this authorChunmiao Liu
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Search for more papers by this authorYanhong Ma
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Search for more papers by this authorYuciu Meng
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Search for more papers by this authorYuxin Wang
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Search for more papers by this authorXiaoli Zhao
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Search for more papers by this authorRu Liu
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Search for more papers by this authorCaixia Li
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Search for more papers by this authorYu Wang
Children's Hospital of Shanghai, Jiaotong University, Shanghai, China
Search for more papers by this authorWeina Ju
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
Search for more papers by this authorEdmund C. Jenkins
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
Search for more papers by this authorW. Ted Brown
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
Search for more papers by this authorCorresponding Author
Nanbert Zhong
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Chinese Alliance of Translational Medicine for Maternal and Children's Health, Shijiazhuang, China
Children's Hospital of Shanghai, Jiaotong University, Shanghai, China
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
Peking University Center of Medical Genetics, Beijing, China
Correspondence
Nanbert Zhong, Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA.
E-mail: [email protected]
Search for more papers by this authorHong Wang
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Chinese Alliance of Translational Medicine for Maternal and Children's Health, Shijiazhuang, China
These authors contributed equally to this work.Search for more papers by this authorQingying Cao
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Chinese Alliance of Translational Medicine for Maternal and Children's Health, Shijiazhuang, China
These authors contributed equally to this work.Search for more papers by this authorJun Ge
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Chinese Alliance of Translational Medicine for Maternal and Children's Health, Shijiazhuang, China
These authors contributed equally to this work.Search for more papers by this authorChunmiao Liu
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Search for more papers by this authorYanhong Ma
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Search for more papers by this authorYuciu Meng
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Search for more papers by this authorYuxin Wang
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Search for more papers by this authorXiaoli Zhao
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Search for more papers by this authorRu Liu
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Search for more papers by this authorCaixia Li
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Search for more papers by this authorYu Wang
Children's Hospital of Shanghai, Jiaotong University, Shanghai, China
Search for more papers by this authorWeina Ju
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
Search for more papers by this authorEdmund C. Jenkins
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
Search for more papers by this authorW. Ted Brown
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
Search for more papers by this authorCorresponding Author
Nanbert Zhong
Shijiazhuang Obstetric and Maternal Health Hospital, Shijiazhuang, China
Chinese Alliance of Translational Medicine for Maternal and Children's Health, Shijiazhuang, China
Children's Hospital of Shanghai, Jiaotong University, Shanghai, China
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
Peking University Center of Medical Genetics, Beijing, China
Correspondence
Nanbert Zhong, Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA.
E-mail: [email protected]
Search for more papers by this authorAbstract
Problem
Spontaneous abortion (SA) occurs before 20 gestational weeks. Approximately, half of recurrent SA has no identifiable cause. No report has yet been investigated the possible involvement of lncRNA in pregnancy loss.
Method of Study
Sixteen pairs of pregnancies with spontaneous abortions (SA) and induced abortions (IA) were studied. Embryonic sacs and decidua were collected for each pregnancy. A Human LncRNA Array was employed to profile genomewide lncRNAs, which were then validated by RT-PCR.
Results
Differentially expressed lncRNAs were identified. Biological pathways were categorized into six major groups: infection and inflammation, metabolism, signaling and transcriptional regulation, smooth muscle contraction, cell process, and coagulation.
Conclusions
Infection and inflammation pathways regulated by lncRNAs were determined as the predominant pathogenetic factors underlying the SA. Finding that antisense lncRNAs have been either up- or down-regulated suggests that they may have both cis- and trans-regulations.
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