Factors associated with fertility intention among women with systemic lupus erythematosus in China: A cross-sectional study
Qian Liang
Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China
Search for more papers by this authorXingxin Wang
Department of Pulmonary and Critical care Medicine, Second Affiliated Hospital of Soochow University, Suzhou, China
Search for more papers by this authorQian He
Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China
Search for more papers by this authorXiaowei Ni
Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China
Search for more papers by this authorRui Zhao
Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China
Search for more papers by this authorJuan Ji
Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China
Search for more papers by this authorCorresponding Author
Chen Dong
Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China
Correspondence
Zhifeng Gu and Chen Dong, Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Zhifeng Gu
Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China
Correspondence
Zhifeng Gu and Chen Dong, Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
Email: [email protected] and [email protected]
Search for more papers by this authorQian Liang
Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China
Search for more papers by this authorXingxin Wang
Department of Pulmonary and Critical care Medicine, Second Affiliated Hospital of Soochow University, Suzhou, China
Search for more papers by this authorQian He
Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China
Search for more papers by this authorXiaowei Ni
Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China
Search for more papers by this authorRui Zhao
Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China
Search for more papers by this authorJuan Ji
Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China
Search for more papers by this authorCorresponding Author
Chen Dong
Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China
Correspondence
Zhifeng Gu and Chen Dong, Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Zhifeng Gu
Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China
Correspondence
Zhifeng Gu and Chen Dong, Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
Email: [email protected] and [email protected]
Search for more papers by this authorQian Liang, Xingxin Wang and Qian He contributed equally to this work.
Abstract
Objective
This study aims to explore the status and influencing factors of fertility intention in women of childbearing age with systemic lupus erythematosus (SLE).
Methods
A total of 158 SLE patients admitted to the Affiliated Hospital of Nantong University from February 2021 to February 2022 were selected for a cross-sectional study. The dependent variable in this study was the fertility intention of lupus women of childbearing age, so the questionnaire was selected: “In view of your disease, do you plan to have children? Yes/no” as the measurement statement. Lupus patients were divided into fertility intention groups and non-fertility intention groups. The questionnaire survey comprises following scales: Hospital Anxiety and Depression Scale (HADS), Multidimensional Fatigue Inventory (MFI-20), Female Sexual Distress Scale-Revised (FSDS-R), and others. Independent t-test, one-way ANOVA, Mann–Whitney U test, and binary logistic regression were used for analysis.
Results
The results showed that 20.9% of lupus patients in this study had a fertility intention. The fertility intention was associated with age, reproductive history, reproductive concerns, sexual distress, fatigue, family function, social support, depression, and sleep. Binary logistic regression showed that physical fatigue (OR 3.56, 95% CI 1.048–12.07) and personal health (OR 2.50, 95% CI 1.065–5.853) had significant predictors of fertility intention.
Conclusion
Our study identified a lower fertility intention in SLE patients who had reproductive concerns, sexual distress, family dysfunction, and fatigue. We encourage healthcare institutions to provide counseling services to all the SLE patients who have fertility intention and focus more on those who have requirements for fertility.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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