Endotoxin concentration and persistent eczema in early childhood
Makoto Irahara
Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Kiwako Yamamoto-Hanada
Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Correspondence
Kiwako Yamamoto-Hanada, Allergy Center, Medical Support Center for Japan Environment and Children's Study, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-0074, Japan,
Email: [email protected]
Search for more papers by this authorMiori Sato
Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorMayako Saito-Abe
Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorYumiko Miyaji
Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorLimin Yang
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorMinaho Nishizato
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorNatsuhiko Kumasaka
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorHidetohi Mezawa
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorYukihiro Ohya
Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorJapan Environment and Children's Study (JECS) Group
See Acknowledgement for The Members of the JECS Group as of 2022.
Search for more papers by this authorMakoto Irahara
Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Kiwako Yamamoto-Hanada
Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Correspondence
Kiwako Yamamoto-Hanada, Allergy Center, Medical Support Center for Japan Environment and Children's Study, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-0074, Japan,
Email: [email protected]
Search for more papers by this authorMiori Sato
Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorMayako Saito-Abe
Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorYumiko Miyaji
Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorLimin Yang
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorMinaho Nishizato
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorNatsuhiko Kumasaka
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorHidetohi Mezawa
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorYukihiro Ohya
Allergy Center, National Center for Child Health and Development, Tokyo, Japan
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorJapan Environment and Children's Study (JECS) Group
See Acknowledgement for The Members of the JECS Group as of 2022.
Search for more papers by this authorAbstract
Although endotoxin concentration in the environment is negatively associated with atopic dermatitis (AD) onset in early childhood, the association between endotoxin concentration in the environment and eczema resolution in children with preexisting eczema is unclear. The aim of this study was to evaluate the association between endotoxin concentration in house dust and eczema persistence in young children. The authors used data from children participating in JECS (Japan Environment and Children's Study). In children who had AD or AD-like lesions at the age of 1 year, the authors investigated the association between the prevalence of eczema at the age of 3 years and endotoxin concentration (categorized by quartiles) in the dust on children's mattresses at the ages of 1.5 and 3 years. This study included 605 children. Eczema was significantly less prevalent among children whose mattresses were in the second and third quartiles of endotoxin concentration when they were 18 months old than among children whose mattresses were in the first quartile (adjusted odds ratio, 0.57 [95% confidence interval, 0.35-0.93] and adjusted odds ratio, 0.49 [95% confidence interval, 0.29–0.83], respectively). Moreover, of the children with eczema at age 3 years, those whose mattresses had endotoxin concentrations in the first quartile had significantly worse sleep disturbance caused by itchy rash (>1 time per week) than did those whose mattresses were in the third and fourth quartiles (20.0% vs 3.3% and 3.7%, both p values < 0.01). The findings indicate that low endotoxin exposure is associated with a higher prevalence of persistent eczema during early childhood.
CONFLICT OF INTEREST
M.I. reports grants from grants-in-aid for scientific research and speaking fees from KYORIN Pharmaceutical Co., Ltd. and Tokushima Medical Association.
Open Research
DATA AVAILABILITY STATEMENT
Data are unsuitable for public deposition because of ethical restrictions and the legal framework of Japan. It is prohibited by the Act on the Protection of Personal Information (Act No. 57 of May 30, 2003, amendment on September 9, 2015) to publicly deposit the data containing personal information. Ethical guidelines for medical and health research involving human subjects enforced by the Japan Ministry of Education, Culture, Sports, Science and Technology and the Ministry of Health, Labour and Welfare also restricts the open sharing of the epidemiologic data. All inquiries about access to data should be sent to: [email protected]. The person responsible for handling enquiries sent to this e-mail address is Dr Shoji F. Nakayama, JECS Programme Office, National Institute for Environmental Studies. URL https://www.env.go.jp/chemi/ceh/en/index.html. The authors had no special access privileges to the data others would not have.
Supporting Information
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| jde16686-sup-0002-TableS1.docxWord 2007 document , 17.5 KB |
Table S1 |
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