RESEARCH NOTE
Calcipotriol induces the production of CTACK/CCL27, one of the potential suppressive factors in psoriasis inflammation
Masaru Karakawa,
Masaru Karakawa
Department of Dermatology, The Jikei University School of Medicine, Minato-ku, Japan
Search for more papers by this author Megumi Kishimoto,
Megumi Kishimoto
Department of Dermatology, Jichi Medical University, Shimotsuke, Japan
Search for more papers by this author Mamitaro Ohtsuki,
Mamitaro Ohtsuki
Department of Dermatology, Jichi Medical University, Shimotsuke, Japan
Search for more papers by this author Mayumi Komine,
Corresponding Author
Mayumi Komine
Department of Dermatology, Jichi Medical University, Shimotsuke, Japan
Correspondence
Mayumi Komine, Department of Dermatology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
Email: [email protected]
Search for more papers by this author
Masaru Karakawa,
Masaru Karakawa
Department of Dermatology, The Jikei University School of Medicine, Minato-ku, Japan
Search for more papers by this author Megumi Kishimoto,
Megumi Kishimoto
Department of Dermatology, Jichi Medical University, Shimotsuke, Japan
Search for more papers by this author Mamitaro Ohtsuki,
Mamitaro Ohtsuki
Department of Dermatology, Jichi Medical University, Shimotsuke, Japan
Search for more papers by this author Mayumi Komine,
Corresponding Author
Mayumi Komine
Department of Dermatology, Jichi Medical University, Shimotsuke, Japan
Correspondence
Mayumi Komine, Department of Dermatology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
Email: [email protected]
Search for more papers by this author
First published: 10 September 2021
No abstract is available for this article.
CONFLICT OF INTEREST
None declared.
REFERENCES
- 1Reiss Y, Proudfoot AE, Power CA, Campbell JJ, Butcher EC. CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. J Exp Med. 2001; 194: 1541–7.
- 2Li C, Xu M, Coyne J, Wang WB, Davila ML, Wang Y, et al. Psoriasis-associated impairment of CCL27/CCR10-derived regulation leads to IL-17A/IL-22-producing skin T-cell overactivation. J Allergy Clin Immunol. 2021; 147: 759–63.e9.
- 3Karakawa M, Komine M, Hanakawa Y, Tsuda H, Sayama K, Tamaki K, et al. CCL27 is downregulated by interferon gamma via epidermal growth factor receptor in normal human epidermal keratinocytes. J Cell Physiol. 2014; 229: 1935–45.
- 4Oshio T, Komine M, Tsuda H, Tominaga SI, Saito H, Nakae S, et al. Nuclear expression of IL-33 in epidermal keratinocytes promotes wound healing in mice. J Dermatol Sci. 2017; 85: 106–14.
- 5Nibbs RJ, Graham GJ. CCL27/PESKY: a novel paradigm for chemokine function. Expert Opin Biol Ther. 2003; 3: 15–22.
- 6Meephansan J, Komine M, Tsuda H, Ohtsuki M. Suppressive effect of calcipotriol on the induction of matrix metalloproteinase (MMP)-9 and MMP-13 in a human squamous cell carcinoma cell line. Clin Exp Dermatol. 2012; 37: 889–96.
- 7Johansen C, Kragballe K, Raumussen M, Dam TN, Iversen L. Activator protein 1 DNA binding activity is decreased in lesional psoriatic skin compared with nonlesional psoriatic skin. Br J Dermatol. 2004; 151: 600–7.
