Volume 56, Issue 6 pp. 653-654

cis-[(4R,5R)-4,5-Bis­(amino­methyl)-2,2-di­methyl-1,3-dioxolane-N,N′](malonato-O,O′)­platinum(II), an anticancer agent

First published: 30 June 2004
Whanchul Shin, e-mail: [email protected]

Abstract

In the title compound, [Pt(C3H2O4)(C7H16N2O2)], the Pt atom is coordinated to two O and two N atoms in a square-planar arrangement. The two independent mol­ecules, which have very similar structures, are approximately related by pseudo-twofold screw-axis symmetry. The six-membered chelate ring in the leaving ligand assumes a conformation intermediate between the half-chair and boat forms. The seven-membered ring in the carrier ligand assumes a twist-chair conformation and the oxolane ring assumes an envelope conformation. The crystal packing consists of extensive hydrogen-bonding networks which form two-dimensional molecular layers, and there are weak van der Waals interactions between these layers.

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