Liver Tumours in Children
The Hepatologist's View
Corresponding Author
Chayarani Kelgeri
Paediatric Liver Unit including Intestinal Transplantation, Birmingham Women's and Children's NHS Foundation Trust, UK
Address correspondence and reprint requests to Chayarani Kelgeri, Liver Unit (including intestinal transplantation), Birmingham Women's and Children's NHS Foundation Trust, Steel house Lane, Birmingham B4 6NH, UK (e-mail: [email protected]).Search for more papers by this authorDiane Renz
Institute of Diagnostic and Interventional Radiology, Department of Paediatric Radiology, Medizinische Hochschule Hannover, Germany
Search for more papers by this authorSimon McGuirk
Department of Radiology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK
Search for more papers by this authorIrene Schmid
Paediatric Oncology, Ludwig Maximilians University, Munich, Germany
Search for more papers by this authorKhalid Sharif
Paediatric Liver Unit including Intestinal Transplantation, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK
Search for more papers by this authorUlrich Baumann
Paediatric Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany
Search for more papers by this authorCorresponding Author
Chayarani Kelgeri
Paediatric Liver Unit including Intestinal Transplantation, Birmingham Women's and Children's NHS Foundation Trust, UK
Address correspondence and reprint requests to Chayarani Kelgeri, Liver Unit (including intestinal transplantation), Birmingham Women's and Children's NHS Foundation Trust, Steel house Lane, Birmingham B4 6NH, UK (e-mail: [email protected]).Search for more papers by this authorDiane Renz
Institute of Diagnostic and Interventional Radiology, Department of Paediatric Radiology, Medizinische Hochschule Hannover, Germany
Search for more papers by this authorSimon McGuirk
Department of Radiology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK
Search for more papers by this authorIrene Schmid
Paediatric Oncology, Ludwig Maximilians University, Munich, Germany
Search for more papers by this authorKhalid Sharif
Paediatric Liver Unit including Intestinal Transplantation, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK
Search for more papers by this authorUlrich Baumann
Paediatric Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany
Search for more papers by this authorSupplemental Digital Content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal's Web site (www.jpgn.org).
The authors report no conflicts of interest.
ABSTRACT
Diagnostic and therapeutic innovations have changed the way we now approach liver tumours in children and adolescents. Novel imaging tools, increasing awareness, and surveillance has led to early diagnosis of benign and malignant liver tumours. Multidisciplinary interventions have favourably altered the natural course in some liver tumours. The role of liver transplantation is expanding and has become fully integrated into today's therapeutic algorithms. Transarterial locoregional and ablation therapies have been successful in adults and are being explored in children to facilitate resectability and improve outcome. For the first time, North American, Japanese, and European experts have designed a global trial to optimize management of malignant liver tumours and aim to find signature molecular profiles that will translate to individualised treatment strategies.
This article aims to offer an overview of recent advances in our understanding of liver tumours in children. It focuses on the paediatric hepatologist's view and their role in the multidisciplinary management of benign and malignant liver tumours.
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