Volume 71, Issue 4 pp. 524-529
Original Article: Gastroenterology: Eosinophilic Gastrointestinal GI Disease

High Patient Disease Burden in a Cross-sectional, Multicenter Contact Registry Study of Eosinophilic Gastrointestinal Diseases

Elizabeth T. Jensen

Corresponding Author

Elizabeth T. Jensen

Department of Epidemiology and Prevention, Wake Forest School of Medicine

Address correspondence and reprint requests to Elizabeth T. Jensen, MPH, PhD, Division of Public Health Sciences, Department of Epidemiology and Prevention, Medical Center Boulevard, Wake Forest University School of Medicine, Winston-Salem, NC 27157 (e-mail: [email protected]).Search for more papers by this author
Seema S. Aceves

Seema S. Aceves

Division of Rheumatology, Allergy, and Immunology, University of California San Diego

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Peter A. Bonis

Peter A. Bonis

Division of Gastroenterology, Tufts University School of Medicine

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Kimberly Bray

Kimberly Bray

USF Health Informatics Institute, University of South Florida

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Wendy Book

Wendy Book

American Partnership for Eosinophilic Disorders (APFED)

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Mirna Chehade

Mirna Chehade

Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai

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Margaret H. Collins

Margaret H. Collins

Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center

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Evan S. Dellon

Evan S. Dellon

Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill

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Gary W. Falk

Gary W. Falk

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania

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Nirmala Gonsalves

Nirmala Gonsalves

Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University

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Sandeep K. Gupta

Sandeep K. Gupta

Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Illinois College of Medicine

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Ikuo Hirano

Ikuo Hirano

Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University

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David A. Katzka

David A. Katzka

Mayo Clinic

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Shay Kyle

Shay Kyle

Campaign Urging Research for Eosinophilic Disease (CURED) Foundation

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Denise Mack

Denise Mack

American Partnership for Eosinophilic Disorders (APFED)

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Ellyn Kodroff

Ellyn Kodroff

Campaign Urging Research for Eosinophilic Disease (CURED) Foundation

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John Leung

John Leung

Center for Food Related Studies, Tufts Medical Center

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Vincent A. Mukkada

Vincent A. Mukkada

Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine

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Melissa Scott

Melissa Scott

Eosinophilic Family Coalition

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Ally Paliana

Ally Paliana

Campaign Urging Research for Eosinophilic Disease (CURED) Foundation

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Kathleen Sable

Kathleen Sable

American Partnership for Eosinophilic Disorders (APFED)

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Jonathan M. Spergel

Jonathan M. Spergel

Division of Allergy-Immunology, Department of Pediatrics, Children's Hospital of Pennsylvania, Perelman School of Medicine at University of Pennsylvania

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Mary Jo Strobel

Mary Jo Strobel

American Partnership for Eosinophilic Disorders (APFED)

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Jeffrey Krischer

Jeffrey Krischer

USF Health Informatics Institute, University of South Florida

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Marc E. Rothenberg

Marc E. Rothenberg

Department of Pediatrics, Cincinnati Children's Hospital Medical Center

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Pablo Abonia

Pablo Abonia

Department of Pediatrics, Cincinnati Children's Hospital Medical Center

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CEGIR Investigator group

CEGIR Investigator group

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First published: 13 June 2020
Citations: 25

The authors report no conflicts of interest.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal's Web site (www.jpgn.org).

ABSTRACT

Objectives:

Clinical features of eosinophilic esophagitis (EoE) have been well-described in the literature, however, characterization of features experienced by patients with other eosinophilic gastrointestinal diseases (EGIDs) is lacking. Using data collected from a patient contact registry, we sought to characterize and contrast patient-reported gastrointestinal and extragastrointestinal symptoms and comorbidities in non-EoE EGIDs, including eosinophilic gastritis, gastroenteritis and colitis, relative to EoE.

Methods:

We conducted a cross-sectional study of contact registry data collected from 2015 to 2018. Statistical comparisons were made using chi-square (categorical measures) and the Mann-Whitney U test (continuous measures). Multivariable analyses were used to evaluate associations between treatment and feelings of isolation.

Results:

Of the 715 reporting an EGID diagnosis (n = 525 EoE; n = 190 non-EoE EGID), a higher proportion of those with a non-EoE EGID reported more frequent specific and nonspecific gastrointestinal symptoms, including nausea, abdominal pain, diarrhea, constipation, and bloating (P < 0.01 for all). Participants with a non-EoE EGID were more likely to report higher frequency of fatigue, isolation, and deep muscle or joint pain (P < 0.01 for all). Specific food elimination and elemental formula treatments were associated with increased odds of more frequent (at least weekly) feelings of isolation for participants with EoE (adjusted odds rtaio [aOR]: 2.4; 95% confidence interval [CI]: 1.5--4.1 for specific food elimination and adjusted OR: 1.9; 95% CI: 1.2--3.3 for elemental formula).

Conclusions:

Significant differences exist in the symptoms and comorbidities experienced between those with EoE versus non-EoE EGIDs. Additional investigation is needed to elucidate the factors that may contribute to the high disease burden of these poorly understood conditions.

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.