Letter to the Editor
Transaminases and Pediatric Nonalcoholic Fatty Liver Disease Diagnosis
First published: 01 November 2017
No abstract is available for this article.
REFERENCES
- 1.Vos MB, Abrams SH, Barlow SE, et al. NASPGHAN clinical practice guideline for the diagnosis and treatment of nonalcoholic fatty liver disease in children: recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN). J Pediatr Gastroenterol Nutr 2017; 64: 319–334.
- 2.Franzese A, Vajro P, Argenziano A, et al. Liver involvement in obese children. Ultrasonography and liver enzyme levels at diagnosis and during follow-up in an Italian population. Dig Dis Sci 1997; 42: 1428–1432.
- 3.Fracanzani AL, Valenti L, Bugianesi E, et al. Risk of severe liver disease in non alcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes. Hepatology 2008; 48: 792–798.
- 4.Portillo-Sanchez P, Bril F, Maximos M, et al. High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels. J Clin Endocrinol Metab 2015; 100: 2231–2238.
- 5.Manco M, Alisi A, Nobili V. Risk of severe liver disease in NAFLD with normal ALT levels: a pediatric report. Hepatology 2008; 48: 2087–2088.
- 6.Molleston JP, Schwimmer JB, Yates KP, et al. on behalf of the NASH Clinical Research Network. Histological abnormalities in children with nonalcoholic fatty liver disease and normal or mildly elevated alanine aminotransferase levels. J Pediatr 2014; 164: 707–713.
- 7.Kohli R. There's more under the nonalcoholic fatty liver disease umbrella than an elevated alanine aminotransferase level. J Pediatr 2014; 164: 684–686.
- 8.Troisi J, Pierri L, Landolfi A, et al. A urinary metabolomic signature of pediatric obesity related liver disease. ESPGHAN 49th Annual Meeting, Athens 2016. J Pediatr Gastroenterol Nutr 2016; 62 (suppl 1): 561–562.
- 9.Sookoian S, Castano GO, Scian R, et al. Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level. Am J Clin Nutr 2016; 103: 422–434.
- 10.Vajro P, Maddaluno S, Veropalumbo C. Persistent hypertransaminasemia in asymptomatic children: a stepwise approach. World J Gastroenterol 2013; 19: 2740–2751.