Ascorbic acid and uric acid levels in lung cancer patients
A. Bozkır,
B. Şimşek,
A. Güngör,
M. Torun,
A. Bozkır
* Department of Biochemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey
Search for more papers by this authorB. Şimşek
* Department of Biochemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey
Search for more papers by this authorA. Güngör
† Department of Chest Surgery, Faculty of Medicine, Ankara University, Ankara, Turkey
Search for more papers by this authorM. Torun
* Department of Biochemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey
Search for more papers by this authorA. Bozkır,
B. Şimşek,
A. Güngör,
M. Torun,
A. Bozkır
* Department of Biochemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey
Search for more papers by this authorB. Şimşek
* Department of Biochemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey
Search for more papers by this authorA. Güngör
† Department of Chest Surgery, Faculty of Medicine, Ankara University, Ankara, Turkey
Search for more papers by this authorM. Torun
* Department of Biochemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey
Search for more papers by this authorTorun Meral Biochemistry Department, Faculty of Pharmacy, Gazi University, 06330, Etiler, Ankara, Turkey. Fax: 90 233 5018.
Summary
Objective: To study any possible association between serum ascorbic acid and uric acid levels with lung cancer.
Method: Serum ascorbic acid and uric acid levels in lung cancer patients (n=30) and healthy controls (n=45) were measured.
Results: The mean values for serum ascorbic acid were found to be significantly lower (P< 0·05) in patients (0·112±0·020) than in controls (0·394±0·029). Serum uric acid levels of patients were also significantly lower than those of controls (P< 0·05).
Conclusion: There was no association between serum levels of ascorbic acid and uric acid, cholesterol, triglyceride and albumin levels with lung cancer.
References
- Junod AF. (1989) Oxygen free radicals and lungs. International Care Medicine, 15, 21-23.
- Cross CE, Halliwell B, Borish ET, et al . (1987) Oxygen radicals and human disease. Annals of Internal Medicine, 107, 526-545.
- Machlin LJ, Bendich A. (1987) Free radical tissue damage: protective role of antioxidant nutrients. Federation of American Societies for Experimental Biology Journal, 1, 441-445.
- Niki E. (1991) Action of ascorbic acid as a scavenger of active and stable oxygen radicals. American Journal of Clinical Nutrition, 54, 1119S-1124S.
- Diplock AT. (1991) Antioxidant nutrients and disease prevention: an overview. American Journal of Clinical Nutrition, 53, 189S-193S.
- Ames BN. (1983) Dietary carcinogens and anticarcinogens. Science, 221, 1256-1264.
- Niki E. (1991) Vitamin C as an antioxidant. World Review Nutrition Dietary, 64, 1-30.
- Ames BN, et al . (1981) Uric acid provides an antioxidant defense in humans against oxidant-and radical-caused ageing and cancer: a hypothesis. Proceedings the National Academy of Sciences of the USA, 78, 6858-6862.
- Kromhout D. (1987) Essential micronutrients in relation to carcinogenesis. American Journal of Clinical Nutrition, 45, 1361-1367.
- Frei B. (1991) Ascorbic acid protects lipids in human plasma and low-density lipoprotein against oxidative damage. American Journal of Clinical Nutrition, 54, 1113S-1118S.
- Frei B, England L, Ames BN. (1989) Ascorbate is an outstanding antioxidant in human blood plasma. Proceedings the National Academy of Sciences of the USA, 86, 6377-6381.
- Frei B, Stocker R, Ames BN. (1988) Antioxidant defenses and lipid peroxidation in human blood plasma. Proceedings the National Academy of Sciences of the USA, 85, 9748-9752.
- Sies H, Stahl W, Sundquist AR. (1992) Antioxidant functions of vitamins: vitamins E and C, beta-carotene, and other carotenoids. Annals New York Academy of Sciences, 669, 7-20.
- Sauberlich HE. (1994) Pharmacology of vitamin C. Annual Review Nutrition, 14, 371-391.
- Hatch LL, Sevanian A. (1984) Measurement of uric acid, ascorbic acid and related metabolites in biological fluids. Analytical Biochemistry, 138, 324-328.
- Rodkey FL. (1965) Direct spectrophotometric determination of albumin in human serum. Clinical Chemistry, 11, 478-487.
- Meiattini F, Prencipe L, Bardelli F, Giannini G, Tarli P. (1978) The hydroxybenzoate/4-aminophenazone chromogenic system used in the enzymatic determination of serum cholesterol. Clinical Chemistry, 24(12), 2161-2165.
- Fossati P, Prencipe L. (1982) Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clinical Chemistry, 28, 2077-2080.
- Block G. (1992) Vitamin C status and cancer. Epidemiologic evidence of reduced risk. Annals New York Academy of Sciences, 669, 280-290.
- Frei B, Roland S, England L, Ames BN. (1990) Ascorbate: the most effective antioxidant in human blood plasma. In: Emerit I et al., eds. Antioxidants in Therapy and Preventive Medicine New York: Plenum Press, 155-163.
- Buettner GR. (1993) The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ASC. Archives of Biochemistry and Biophysics, 300, 535-543.
- Levine M. (1986) New concepts in the biology and biochemistry of ascorbic acid. New England Journal of Medicine, 314, 892-902.
- Hanck AB. (1988) Vitamin C and cancer. Progress in Clinical Biological Research, 259, 307-320.
- Block G. (1991) Epidemiologic evidence regarding vitamin C and cancer. American Journal of Clinical Nutrition, 54, 1310S-1314S.
- Gershoff SN. (1993) Vitamin C (ascorbic acid): new roles, new requirements Nutrition Reviews, 51(11), 313-326.
- Knekt P, Järvinen R, Seppänen R, et al . (1991) Dietary antioxidants and the risk of lung cancer. American Journal of Epidemiology, 134(5), 471-479.
- Gey KF, Brubacher GB, Stahelin HB. (1987) Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer. American Journal of Clinical Nutrition, 45, 1368-1377.
- Hiatt RA, Fireman BH. (1988) Serum uric acid unrelated to cancer incidence in humans. Cancer Research, 48, 2916-2918.
- Peterson B, Trell E. (1983) Raised serum urate concentration as risk factor for premature mortality in middle aged men: relation to death from cancer. British Medical Bulletin, 287, 7-9.
- Lickl E, Alth G, Ebermann R, Beck RH, Tuma K. (1989) Serum urate level and cancer. Medical Hypotheses, 28, 193-195.
- Burgaz S, Torun M, Yardım S, Sargın H, Orman MN, Özdamar NY. (1996) Serum carotenoids and uric acid levels in relation to cancer. Journal of Clinical Pharmacy and Therapeutics, 21, 331-336.
- Torun M, Yardım S, Şimşek B, Burgaz S. (1998) Serum uric acid levels in cardiovascular diseases. Journal of Clinical Pharmacy and Therapeutics, 23, 25-29.
- Sevanian A, Davies KJA, Hochstein P. (1991) Serum urate as an antioxidant for ascorbic acid. American Journal of Clinical Nutrition, 54, 1129S-1134S.
- Block G. (1991) Vitamin C and cancer prevention: the epidemiologic evidence. American Journal of Clinical Nutrition, 53, 270S-282S.
- Pauling L. (1980) Vitamin C therapy of advanced cancer. New England Journal of Medicine, 302, 694-698.
- Vojdani A, Ghoneum G. (1993) In vivo effect of ascorbic acid on enhancement of human natural killer cell activity. Nutrition Research, 13, 753-764.
- Torun M, Yardım S, Gönenç A, Sargın H, Menevşe A. (1995) Serum β-carotene, vitamin E, vitamin C and malondialdehyde levels in several types of cancer. Journal of Clinical Pharmacy and Therapeutics, 20, 259-263.
- Torun M, Yardım S, Bozkır A, Şimşek B. (1995) Serum vitamin C and uric acid levels in relation to cancer. Journal of Faculty of Gazi University, 12(2), 1-5.
