Elevated levels of cyclin A1 and A (A2) mRNA in acute myeloid leukaemia are associated with increased survival
Tsuyoshi Nakamaki,
Yasuharu Hamano,
Jun-ichi Hisatake,
Akihiro Yokoyama,
Kei-ichiro Kawakami,
Shigeru Tomoyasu,
Yoshio Honma,
Phillip Koeffler,
Tsuyoshi Nakamaki
Department of Haematology, Showa University School of Medicine, Tokyo
Search for more papers by this authorYasuharu Hamano
Department of Haematology, Showa University School of Medicine, Tokyo
Search for more papers by this authorJun-ichi Hisatake
Department of Haematology, Showa University School of Medicine, Tokyo
Search for more papers by this authorAkihiro Yokoyama
Department of Haematology, Showa University School of Medicine, Tokyo
Search for more papers by this authorKei-ichiro Kawakami
Department of Haematology, Showa University School of Medicine, Tokyo
Search for more papers by this authorShigeru Tomoyasu
Department of Haematology, Showa University School of Medicine, Tokyo
Search for more papers by this authorYoshio Honma
Department of Chemotherapy, Saitama Cancer Centre Research Institute, Saitama, Japan
Search for more papers by this authorPhillip Koeffler
Division of Hematology/Oncology, Cedars-Sinai Research Institute/UCLA School of Medicine, Los Angeles, CA, USA
Search for more papers by this authorTsuyoshi Nakamaki,
Yasuharu Hamano,
Jun-ichi Hisatake,
Akihiro Yokoyama,
Kei-ichiro Kawakami,
Shigeru Tomoyasu,
Yoshio Honma,
Phillip Koeffler,
Tsuyoshi Nakamaki
Department of Haematology, Showa University School of Medicine, Tokyo
Search for more papers by this authorYasuharu Hamano
Department of Haematology, Showa University School of Medicine, Tokyo
Search for more papers by this authorJun-ichi Hisatake
Department of Haematology, Showa University School of Medicine, Tokyo
Search for more papers by this authorAkihiro Yokoyama
Department of Haematology, Showa University School of Medicine, Tokyo
Search for more papers by this authorKei-ichiro Kawakami
Department of Haematology, Showa University School of Medicine, Tokyo
Search for more papers by this authorShigeru Tomoyasu
Department of Haematology, Showa University School of Medicine, Tokyo
Search for more papers by this authorYoshio Honma
Department of Chemotherapy, Saitama Cancer Centre Research Institute, Saitama, Japan
Search for more papers by this authorPhillip Koeffler
Division of Hematology/Oncology, Cedars-Sinai Research Institute/UCLA School of Medicine, Los Angeles, CA, USA
Search for more papers by this authorTsuyoshi Nakamaki, Department of Haematology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. E-mail: [email protected]
Abstract
Summary. Cyclin A (A2) and cyclin A1 are members of the G2 cyclins, which are involved in the control of G2/M and G1/S transitions as well as mitosis. Human cyclin A1 was cloned as an A-type cyclin that is highly expressed in acute myeloid leukaemia (AML). The clinical significance of these cyclins in myeloid leukaemia remains to be clarified. We investigated the relative levels of these transcripts in 80 patients with de novo AML. Correlations with clinical parameters showed that the initial white blood cell count and serum lactate dehydrogenase levels were inversely associated with cyclin A (A2) mRNA levels (r = −0·276, P = 0·019) and cyclin A1 mRNA levels (r = −0·241, P = 0·042) respectively. They were independently associated with increased overall survival [P = 0·035 for cyclin A (A2) and P = 0·016 for cyclin A1]. Multivariate analysis using Cox's proportional hazard model showed that elevated cyclin A1 mRNA levels contributed significantly to the better prognosis of patients with AML. Furthermore, the analysis of survival probability showed that the group with high levels of both cyclin A (A2) and A1 survived significantly longer than the group with low expression of both these cyclins (P = 0·002). These data indicate that high expression levels of both cyclin A (A2) and A1 are associated with good prognosis in AML patients.
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