Stability of intravesical epirubicin infusion: a sequential temperature study
Professor Graham J. Sewell, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK. Tel.: 01225 826773; fax: 01225 826114;
e-mail: [email protected]
Summary
Objective: To investigate the stability of epirubicin bladder instillation, prepared from two different epirubicin formulations, under refrigerated storage, transportation and clinical use conditions.
Method: A sequential study design was used. Epirubicin instillation (1 mg/mL) in polypropylene syringes was sequential incubated for periods of 84 days at 8°C followed by 2 h at 25°C and 1 h at 37°C, the latter two temperatures replicating transport and intravesical conditions, respectively.
Results: The instillation was both chemically and physically stable under those incubation conditions. The formulation of epirubicin used to prepare the instillation infusions did not affect stability.
