Abstract
The Duchenne muscular dystrophy gene is the largest and one of the most complex genes known to date. Four 5′ promoters regulate, in a cell-type-specific manner, the expression of full-length gene product, the protein called dystrophin. In addition, four internal promoters regulate the expression of smaller proteins which lack important parts of dystrophin, and probably have different functions.
References
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Further Reading
- Ahn AH and Kunkel LM (1993) The structural and functional diversity of dystrophin. Nature Genetics 3: 283–291.
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Web Links
- Dystrophin (muscular dystrophy, Duchenne and Becker types) (DMD); Locus ID: 1756. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=1756
- Dystrophin (muscular dystrophy, Duchenne and Becker types) (DMD); MIM number: 300377. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?300377
