Volume 110, Issue 2 pp. 144-148

Osteoblastic activity of the rabbit temporomandibular joint during distraction osteogenesis assessed by [¹⁸F]fluoride positron emission tomography

Arja Muhonen,

Arja Muhonen

Department of Oral and Maxillofacial Surgery, University of Turku, Turku, Finland,

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Timo Peltomäki,

Timo Peltomäki

Department of Oral Development and Orthodontics, University of Turku, Turku, Finland,

Department of Oral Diseases, Turku University Central Hospital, Turku, Finland

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Juhani Knuuti,

Juhani Knuuti

Turku PET Center, University of Turku/Turku University Central Hospital, Turku, Finland,

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Olli Raitakari,

Olli Raitakari

Turku PET Center, University of Turku/Turku University Central Hospital, Turku, Finland,

Department of Clinical Physiology, Turku University Central Hospital, Turku, Finland,

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Risto-Pekka Happonen,

Risto-Pekka Happonen

Department of Oral and Maxillofacial Surgery, University of Turku, Turku, Finland,

Department of Oral Diseases, Turku University Central Hospital, Turku, Finland

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Arja Muhonen,

Arja Muhonen

Department of Oral and Maxillofacial Surgery, University of Turku, Turku, Finland,

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Timo Peltomäki,

Timo Peltomäki

Department of Oral Development and Orthodontics, University of Turku, Turku, Finland,

Department of Oral Diseases, Turku University Central Hospital, Turku, Finland

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Juhani Knuuti,

Juhani Knuuti

Turku PET Center, University of Turku/Turku University Central Hospital, Turku, Finland,

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Olli Raitakari,

Olli Raitakari

Turku PET Center, University of Turku/Turku University Central Hospital, Turku, Finland,

Department of Clinical Physiology, Turku University Central Hospital, Turku, Finland,

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Risto-Pekka Happonen,

Risto-Pekka Happonen

Department of Oral and Maxillofacial Surgery, University of Turku, Turku, Finland,

Department of Oral Diseases, Turku University Central Hospital, Turku, Finland

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First published: 30 April 2002

https://doi.org/10.1034/j.1600-0722.2002.11208.x

Citations: 12

Prof Risto-Pekka Happonen, Department of Oral and Maxillofacial Surgery, University of Turku, Lemminkäisenkatu 2, 20520 Turku, Finland
Telefax: +358–2–2338248
E-mail: [email protected]

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Abstract

The purpose of the study was to evaluate the effects of irradiation and hyperbaric oxygenation (HBO) on osteoblastic activity of the temporomandibular joint (TMJ) region during mandibular distraction osteogenesis. Unilateral distraction was performed on 19 rabbits, which were divided into five groups. One group served as a control group, while the others received either high- or low-dose irradiation in the TMJ region before surgery. Some of the animals were also given HBO 18 times at 2.5 ATA×90 min preoperatively. Osteogenesis was assessed by [¹⁸F]fluoride positron emission tomography at the end of the distraction. Osteoblastic activity was higher on the distracted side in all groups, except in the high-dose irradiated group without preceding HBO. HBO increased osteogenesis on both sides after radiotherapy. It is concluded that increased osteoblastic activity reflects increased pressure on the TMJ region of the distracted side, resulting from lengthening. It seems that more remodeling is required after irradiation than without preceding radiotherapy. After radiotherapy, HBO increased osteoblastic activity.

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Volume110, Issue2

April 2002

Pages 144-148

Osteoblastic activity of the rabbit temporomandibular joint during distraction osteogenesis assessed by [¹⁸F]fluoride positron emission tomography

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Osteoblastic activity of the rabbit temporomandibular joint during distraction osteogenesis assessed by [18F]fluoride positron emission tomography

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Osteoblastic activity of the rabbit temporomandibular joint during distraction osteogenesis assessed by [¹⁸F]fluoride positron emission tomography