New HLA-DRB1* nucleotide sequence of Italian origin: HLA-DRB1*13022
This sequence has been officially named DRB1*13022 (FM99/810, HWS 10000264 – AF217961) by the WHO Nomenclature Committee in December 1999. This follows the agreed policy that, subject to the conditions stated in the most recent Nomenclature Report ( 2), names will be assigned to new sequences as they are identified. Lists of such new names will be published in the following WHO Nomenclature Report.
Abstract:
High-resolution polymerase chain reaction using sequence-specific primer typing of the HLA-DRB1 gene of an Italian patient waiting for unrelated bone marrow transplantation revealed a new allelic variant of HLA-DRB1*13. Sequencing the exon 2 of DRB1* gene demonstrated a G→C transition at the nucleotide 216 resulting in a silent mutation at codon 72: CGG→CGC. The closest sequence was the HLA-DRB1*1302 and the new allele was named HLA-DRB1*13022. This variant was carried by the haplotype HLA-A*24; Cw*0702; B*39; DRB1*13022; DRB3*0301; DQA1*0102; DQB1*0604 as demonstrated by a family study ( Note).
