Type III secretion: The bacteria-eukaryotic cell express
Luís Jaime Mota,
Isabel Sorg,
Guy R. Cornelis,
Luís Jaime Mota
Biozentrum der Universitåt Basel, Biozentrum, Klingelbergstrasse, 50-70 CH4051 Basel, Switzerland
Imperial College London, Centre for Molecular Microbiology and Infection, Armstrong Road, Flowers Building, London SW7 2AZ, United Kingdom.
Search for more papers by this authorIsabel Sorg
Biozentrum der Universitåt Basel, Biozentrum, Klingelbergstrasse, 50-70 CH4051 Basel, Switzerland
Search for more papers by this authorCorresponding Author
Guy R. Cornelis
Biozentrum der Universitåt Basel, Biozentrum, Klingelbergstrasse, 50-70 CH4051 Basel, Switzerland
*Corresponding author. Tel.: + 41 61 267 2121; fax: +41 61 267 2118., E-mail address: [email protected]Search for more papers by this authorLuís Jaime Mota,
Isabel Sorg,
Guy R. Cornelis,
Luís Jaime Mota
Biozentrum der Universitåt Basel, Biozentrum, Klingelbergstrasse, 50-70 CH4051 Basel, Switzerland
Imperial College London, Centre for Molecular Microbiology and Infection, Armstrong Road, Flowers Building, London SW7 2AZ, United Kingdom.
Search for more papers by this authorIsabel Sorg
Biozentrum der Universitåt Basel, Biozentrum, Klingelbergstrasse, 50-70 CH4051 Basel, Switzerland
Search for more papers by this authorCorresponding Author
Guy R. Cornelis
Biozentrum der Universitåt Basel, Biozentrum, Klingelbergstrasse, 50-70 CH4051 Basel, Switzerland
*Corresponding author. Tel.: + 41 61 267 2121; fax: +41 61 267 2118., E-mail address: [email protected]Search for more papers by this authorEdited by I. Henderson
Abstract
Type III secretion (T3S) is an export pathway used by Gram-negative pathogenic bacteria to inject bacterial proteins into the cytosol of eukaryotic host cells. This pathway is characterized by (i) a secretion nanomachine related to the bacterial flagellum, but usually topped by a stiff needle-like structure; (ii) the assembly in the eukaryotic cell membrane of a translocation pore formed by T3S substrates; (iii) a non-cleavable N-terminal secretion signal; (iv) T3S chaperones, assisting the secretion of some substrates; (v) a control mechanism ensuring protein delivery at the right place and time. Here, we review these different aspects focusing in open questions that promise exciting findings in the near future.
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