Clinical Characteristics and Surgical Outcomes of Carotid Body Tumors: Data from the Carotid Paraganglioma Cooperative International Registry (CAPACITY) Group
Mauricio Gonzalez-Urquijo
Tecnologico de Monterrey, School of Medicine and Health Sciences, Av. Ignacio Morones Prieto 3000, Sertoma,, 64710 Monterrey, N.L., Mexico
Search for more papers by this authorVictor Hugo Viteri-Pérez
Hospital de Especialidades Carlos Andrade Marín, Ecuador. Av. Universitaria, 170103 Quito, Ecuador
Search for more papers by this authorAndrea Becerril-Gaitan
Tecnologico de Monterrey, School of Medicine and Health Sciences, Av. Ignacio Morones Prieto 3000, Sertoma,, 64710 Monterrey, N.L., Mexico
Search for more papers by this authorDavid Hinojosa-Gonzalez
Tecnologico de Monterrey, School of Medicine and Health Sciences, Av. Ignacio Morones Prieto 3000, Sertoma,, 64710 Monterrey, N.L., Mexico
Search for more papers by this authorMaría Elizabeth Enríquez-Vega
Hospital de Especialidades CMN La Raza, Av. Hospital Benito Juárez 4, La Raza, Azcapotzalco, 02990 Mexico City, CDMX, Mexico
Search for more papers by this authorIvan Walter Soto Vaca Guzmán
Hospital Obrero Nº1, C. Lucas Jaimes 76La Paz, La Paz, Bolivia
Search for more papers by this authorGregorio Eloy Valda-Ameller
Hospital Santa Bárbara, Destacamento 111, Sucre, Bolivia
Hospital Dr. Jaime Mendoza, El Villar, Sucre, Bolivia
Search for more papers by this authorJosé de Jesús García-Pérez
Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, Doctores, Cuauhtémoc, 06720 Mexico City, CDMX, Mexico
Search for more papers by this authorCarlos Vaquero-Puerta
Hospital Clínico Universitario de Valladolid, Av. Ramón Y Cajal, 3, 47003 Valladolid, Spain
Search for more papers by this authorVictor Hugo Jaramillo-Vergara
Hospital de Especialidades Carlos Andrade Marín, Ecuador. Av. Universitaria, 170103 Quito, Ecuador
Search for more papers by this authorMiguel Angel Cisneros-Tinoco
Instituto Mexicano del Seguro Social (IMSS) UMAE 189, Av. Cuauhtémoc, Formando Hogar, 91810 Veracruz,, Ve, Mexico
Search for more papers by this authorJoaquin Miguel Santoscoy-Ibarra
Hospital Central Universitario, C. Antonio Rosales 33000, Obrera, 31350 Chihuahua, Chih., Mexico
Search for more papers by this authorCorresponding Author
Mario Alejandro Fabiani
Tecnologico de Monterrey, School of Medicine and Health Sciences, Av. Ignacio Morones Prieto 3000, Sertoma,, 64710 Monterrey, N.L., Mexico
[email protected]Search for more papers by this authorEdgar Geovanny Cárdenas-Figueroa
Hospital de Especialidades Carlos Andrade Marín, Ecuador. Av. Universitaria, 170103 Quito, Ecuador
Search for more papers by this authorVerónica Elizabeth Borja-Rojas
Hospital de Especialidades Carlos Andrade Marín, Ecuador. Av. Universitaria, 170103 Quito, Ecuador
Search for more papers by this authorIngrid Valeria Salinas-Ramos
Hospital Obrero Nº1, C. Lucas Jaimes 76La Paz, La Paz, Bolivia
Search for more papers by this authorAlfonso Juan Gonzalez-Valladares
Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, Doctores, Cuauhtémoc, 06720 Mexico City, CDMX, Mexico
Search for more papers by this authorAneiva Claudia Katherine-Perez
Hospital Obrero Nº1, C. Lucas Jaimes 76La Paz, La Paz, Bolivia
Search for more papers by this authorGael Bañuelos-Gutierrez
Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, Doctores, Cuauhtémoc, 06720 Mexico City, CDMX, Mexico
Search for more papers by this authorJesus Isaias Garcia-Palafox
Instituto Mexicano del Seguro Social (IMSS) HGZ 8, CDMX, Mexico
Search for more papers by this authorGregorio Fernando Gardeazabal-Diaz
Hospital Obrero Nº1, C. Lucas Jaimes 76La Paz, La Paz, Bolivia
Search for more papers by this authorCésar Armando López-Aldayuz
Seguro Banca Privada, La Paz, Bolivia
Search for more papers by this authorJosé Ángel Barajas-Colón
Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, Doctores, Cuauhtémoc, 06720 Mexico City, CDMX, Mexico
Search for more papers by this authorMauricio Gonzalez-Urquijo
Tecnologico de Monterrey, School of Medicine and Health Sciences, Av. Ignacio Morones Prieto 3000, Sertoma,, 64710 Monterrey, N.L., Mexico
Search for more papers by this authorVictor Hugo Viteri-Pérez
Hospital de Especialidades Carlos Andrade Marín, Ecuador. Av. Universitaria, 170103 Quito, Ecuador
Search for more papers by this authorAndrea Becerril-Gaitan
Tecnologico de Monterrey, School of Medicine and Health Sciences, Av. Ignacio Morones Prieto 3000, Sertoma,, 64710 Monterrey, N.L., Mexico
Search for more papers by this authorDavid Hinojosa-Gonzalez
Tecnologico de Monterrey, School of Medicine and Health Sciences, Av. Ignacio Morones Prieto 3000, Sertoma,, 64710 Monterrey, N.L., Mexico
Search for more papers by this authorMaría Elizabeth Enríquez-Vega
Hospital de Especialidades CMN La Raza, Av. Hospital Benito Juárez 4, La Raza, Azcapotzalco, 02990 Mexico City, CDMX, Mexico
Search for more papers by this authorIvan Walter Soto Vaca Guzmán
Hospital Obrero Nº1, C. Lucas Jaimes 76La Paz, La Paz, Bolivia
Search for more papers by this authorGregorio Eloy Valda-Ameller
Hospital Santa Bárbara, Destacamento 111, Sucre, Bolivia
Hospital Dr. Jaime Mendoza, El Villar, Sucre, Bolivia
Search for more papers by this authorJosé de Jesús García-Pérez
Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, Doctores, Cuauhtémoc, 06720 Mexico City, CDMX, Mexico
Search for more papers by this authorCarlos Vaquero-Puerta
Hospital Clínico Universitario de Valladolid, Av. Ramón Y Cajal, 3, 47003 Valladolid, Spain
Search for more papers by this authorVictor Hugo Jaramillo-Vergara
Hospital de Especialidades Carlos Andrade Marín, Ecuador. Av. Universitaria, 170103 Quito, Ecuador
Search for more papers by this authorMiguel Angel Cisneros-Tinoco
Instituto Mexicano del Seguro Social (IMSS) UMAE 189, Av. Cuauhtémoc, Formando Hogar, 91810 Veracruz,, Ve, Mexico
Search for more papers by this authorJoaquin Miguel Santoscoy-Ibarra
Hospital Central Universitario, C. Antonio Rosales 33000, Obrera, 31350 Chihuahua, Chih., Mexico
Search for more papers by this authorCorresponding Author
Mario Alejandro Fabiani
Tecnologico de Monterrey, School of Medicine and Health Sciences, Av. Ignacio Morones Prieto 3000, Sertoma,, 64710 Monterrey, N.L., Mexico
[email protected]Search for more papers by this authorEdgar Geovanny Cárdenas-Figueroa
Hospital de Especialidades Carlos Andrade Marín, Ecuador. Av. Universitaria, 170103 Quito, Ecuador
Search for more papers by this authorVerónica Elizabeth Borja-Rojas
Hospital de Especialidades Carlos Andrade Marín, Ecuador. Av. Universitaria, 170103 Quito, Ecuador
Search for more papers by this authorIngrid Valeria Salinas-Ramos
Hospital Obrero Nº1, C. Lucas Jaimes 76La Paz, La Paz, Bolivia
Search for more papers by this authorAlfonso Juan Gonzalez-Valladares
Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, Doctores, Cuauhtémoc, 06720 Mexico City, CDMX, Mexico
Search for more papers by this authorAneiva Claudia Katherine-Perez
Hospital Obrero Nº1, C. Lucas Jaimes 76La Paz, La Paz, Bolivia
Search for more papers by this authorGael Bañuelos-Gutierrez
Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, Doctores, Cuauhtémoc, 06720 Mexico City, CDMX, Mexico
Search for more papers by this authorJesus Isaias Garcia-Palafox
Instituto Mexicano del Seguro Social (IMSS) HGZ 8, CDMX, Mexico
Search for more papers by this authorGregorio Fernando Gardeazabal-Diaz
Hospital Obrero Nº1, C. Lucas Jaimes 76La Paz, La Paz, Bolivia
Search for more papers by this authorCésar Armando López-Aldayuz
Seguro Banca Privada, La Paz, Bolivia
Search for more papers by this authorJosé Ángel Barajas-Colón
Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, Doctores, Cuauhtémoc, 06720 Mexico City, CDMX, Mexico
Search for more papers by this authorAbstract
Background
This study's objective was to conduct a multinational registry of patients with carotid body tumors (CBTs) and to analyze patients’ clinical characteristics, treatments, and outcomes.
Methods
Retrospective study from the Carotid Paraganglioma Cooperative International Registry involving eleven medical centers in Bolivia, Ecuador, Mexico, and Spain, of all patients with a CBT who underwent resection between 2009 and 2019.
Results
A total of 1432 patients with a CBT surgically treated were included. Median patient age was 54 years (range: 45–63 years), and 82.9% (1184) of the study cohort were female. While at low altitude, the proportion of female-to-male cases was 2:1, at high altitude, this proportion increased to 8:1, with statistically significant differences (p = .022). Median operative time was 139 min (range: 110–180 min), while median operative blood loss was 250 ml (range: 100–500 ml), with statistically significant difference in increased blood loss (p = .001) and operative time (p = .001) with a higher Shamblin classification. Eight (0.6%) patients suffered stroke. Univariate analysis analyzing for possible factors associated with increased odds of stroke revealed intraoperative vascular lesion to present an OR of 2.37 [CI 95%; 1.19–4.75] (p = 0.001). In 245 (17.1%), a cranial nerve injury was reported. Seven (0.5%) deaths were recorded.
Conclusion
The most common CBT type on this cohort was hyperplasic, which might be partially explained by the high altitudes where these patients lived. Increased blood loss and operative time were associated with a higher Shamblin classification, and the risk of stroke was associated with patients presenting transoperative vascular lesions.
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