Diagnostic Value of FDG-PET/CT for Lymph Node Metastasis of Colorectal Cancer
Jae Young Kwak
Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, and Asan Medical Center, Seoul, Korea
Search for more papers by this authorJae Seung Kim
Department of Nuclear Medicine, University of Ulsan College of Medicine, and Asan Medical Center, Seoul, Korea
Search for more papers by this authorHye Jin Kim
Department of Radiology, University of Ulsan College of Medicine, and Asan Medical Center, Seoul, Korea
Search for more papers by this authorHyun Kwon Ha
Department of Radiology, University of Ulsan College of Medicine, and Asan Medical Center, Seoul, Korea
Search for more papers by this authorChang Sik Yu
Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, and Asan Medical Center, Seoul, Korea
Search for more papers by this authorCorresponding Author
Jin Cheon Kim
Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, and Asan Medical Center, Seoul, Korea
Department of Surgery, University of Ulsan College of Medicine, 86 Asanbyeongwon-gil, Songpa-gu, 138-736 Seoul, Korea
[email protected]Search for more papers by this authorJae Young Kwak
Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, and Asan Medical Center, Seoul, Korea
Search for more papers by this authorJae Seung Kim
Department of Nuclear Medicine, University of Ulsan College of Medicine, and Asan Medical Center, Seoul, Korea
Search for more papers by this authorHye Jin Kim
Department of Radiology, University of Ulsan College of Medicine, and Asan Medical Center, Seoul, Korea
Search for more papers by this authorHyun Kwon Ha
Department of Radiology, University of Ulsan College of Medicine, and Asan Medical Center, Seoul, Korea
Search for more papers by this authorChang Sik Yu
Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, and Asan Medical Center, Seoul, Korea
Search for more papers by this authorCorresponding Author
Jin Cheon Kim
Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, and Asan Medical Center, Seoul, Korea
Department of Surgery, University of Ulsan College of Medicine, 86 Asanbyeongwon-gil, Songpa-gu, 138-736 Seoul, Korea
[email protected]Search for more papers by this authorPresented at the Annual Meeting of American Society of Colon and Rectal Surgeons, Vancouver, British Columbia, Canada, May 14–18, 2011.
Abstract
Background
Lymph node metastasis is an important prognostic factor in patients with colorectal cancer. We assessed the ability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to diagnose lymph node metastases in colorectal cancer patients.
Methods
We retrospectively analyzed the records of 473 patients who underwent preoperative FDG-PET/CT, followed by curative surgery for colorectal cancer. Lymph node metastases were assessed as proximal or distal, depending on their anatomical location. We analyzed the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of FDG-PET/CT and CT for detecting lymph node metastases.
Results
In detecting proximal lymph nodes, FDG-PET/CT had a sensitivity of 66 %, a specificity of 60 %, a PPV of 63 %, an NPV of 62 %, and an accuracy of 63 %; whereas CT had a sensitivity of 87 %, a specificity of 29 %, a PPV of 57 %, an NPV of 68 %, and an accuracy of 59 % (P = 0.245). FDG-PET/CT and CT also showed similar accuracy in detecting distal lymph nodes (87 vs. 88 %, P = 0.620).
Conclusion
Preoperative FDG-PET/CT and CT have comparable accuracy in detecting lymph node metastases of colorectal cancer.
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