IEEJ Transactions on Electrical and Electronic Engineering

Volume 17, Issue 8 pp. 1228-1230

Letter

Virus Detection using Second Harmonics of Magnetic Nanoparticles

Ryuichi Hirota,

Ryuichi Hirota

Non-member

Graduate School of Engineering, Tohoku University, 6-6-05 Aramaki-aza-Aoba, Aoba-ku, Sendai, Miyagi, 980-8579 Japan

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Toru Murayama,

Toru Murayama

Non-member

Faculty of Engineering, Tohoku Gakuin University, 1-13-1 Chuo, Tagajo, Miyagi, 985-8537 Japan

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Ryota Katsumi,

Ryota Katsumi

Non-member

Graduate School of Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, Aichi, 441-8580 Japan

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Tokuhisa Kawawaki,

Tokuhisa Kawawaki

Non-member

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo, 162-8601 Japan

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Shin Yabukami,

Shin Yabukami

Member

Graduate School of Engineering, Tohoku University, 6-6-05 Aramaki-aza-Aoba, Aoba-ku, Sendai, Miyagi, 980-8579 Japan

Faculty of Engineering, Tohoku Gakuin University, 1-13-1 Chuo, Tagajo, Miyagi, 985-8537 Japan

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Ryuji Igarashi,

Ryuji Igarashi

Non-member

Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa Inage-ku, Chiba, 263-8555 Japan

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Yuichi Negishi,

Yuichi Negishi

Member

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo, 162-8601 Japan

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Moriaki Kusakabe,

Moriaki Kusakabe

Non-member

Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657 Japan

Matrix Cell Research Institute Inc., Ibaraki, 300-1232 Japan

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Masaki Sekino,

Masaki Sekino

Member

Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656 Japan

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Takashi Yatsui,

Takashi Yatsui

Non-member

Graduate School of Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, Aichi, 441-8580 Japan

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Akihiro Kuwahata,

Corresponding Author

Akihiro Kuwahata

Member

[email protected]

Graduate School of Engineering, Tohoku University, 6-6-05 Aramaki-aza-Aoba, Aoba-ku, Sendai, Miyagi, 980-8579 Japan

Correspondence to: Akihiro Kuwahata. E-mail: [email protected]Search for more papers by this author

Ryuichi Hirota,

Ryuichi Hirota

Non-member

Graduate School of Engineering, Tohoku University, 6-6-05 Aramaki-aza-Aoba, Aoba-ku, Sendai, Miyagi, 980-8579 Japan

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Toru Murayama,

Toru Murayama

Non-member

Faculty of Engineering, Tohoku Gakuin University, 1-13-1 Chuo, Tagajo, Miyagi, 985-8537 Japan

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Ryota Katsumi,

Ryota Katsumi

Non-member

Graduate School of Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, Aichi, 441-8580 Japan

Search for more papers by this author

Tokuhisa Kawawaki,

Tokuhisa Kawawaki

Non-member

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo, 162-8601 Japan

Search for more papers by this author

Shin Yabukami,

Shin Yabukami

Member

Graduate School of Engineering, Tohoku University, 6-6-05 Aramaki-aza-Aoba, Aoba-ku, Sendai, Miyagi, 980-8579 Japan

Faculty of Engineering, Tohoku Gakuin University, 1-13-1 Chuo, Tagajo, Miyagi, 985-8537 Japan

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Ryuji Igarashi,

Ryuji Igarashi

Non-member

Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa Inage-ku, Chiba, 263-8555 Japan

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Yuichi Negishi,

Yuichi Negishi

Member

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo, 162-8601 Japan

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Moriaki Kusakabe,

Moriaki Kusakabe

Non-member

Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657 Japan

Matrix Cell Research Institute Inc., Ibaraki, 300-1232 Japan

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Masaki Sekino,

Masaki Sekino

Member

Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656 Japan

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Takashi Yatsui,

Takashi Yatsui

Non-member

Graduate School of Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, Aichi, 441-8580 Japan

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Akihiro Kuwahata,

Corresponding Author

Akihiro Kuwahata

Member

[email protected]

Graduate School of Engineering, Tohoku University, 6-6-05 Aramaki-aza-Aoba, Aoba-ku, Sendai, Miyagi, 980-8579 Japan

Correspondence to: Akihiro Kuwahata. E-mail: [email protected]Search for more papers by this author

First published: 12 April 2022

https://doi.org/10.1002/tee.23613

Citations: 3

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Abstract

Virus detection methods based on the nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic have been widely applied on account of their high sensitivity, short measurement-time, and low cost. In this letter, we propose a virus detection method using the second harmonics to improve the signal intensity. We find that the signal to noise ratio of the second harmonic is approximately three times higher than that of the third harmonic. A comparison of the ratio of the second harmonic to the fourth harmonic (R₂₄) and the ratio of the third harmonic to the fifth harmonic (R₃₅) shows that R₂₄ is more sensitive to identifying changes in virus concentration. Our proposed method has the potential to be utilized for rapid screening on virus detection. © 2022 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.

References

1 Basu S, Mitra S, Saha N. Deep learning for screening COVID-19 using chest X-Ray images. 2020 IEEE SSCI 2020: 2521–2527.
Google Scholar
2Wu K, Liu J, Saha R, Su D, Krishna VD, Cheeran MCJ, Wang JP. Magnetic particle spectroscopy for detection of influenza A virus subtype H1N1. ACS Applied Materials & Interfaces 2020; 12(12): 13686–13697.
10.1021/acsami.0c00815
CAS PubMed Web of Science® Google Scholar
3Wu K, Liu J, Su D, Saha R, Wang JP. Magnetic nanoparticle relaxation dynamics-based magnetic particle spectroscopy for rapid and wash-free molecular sensing. ACS Applied Materials & Interfaces 2019; 11(11): 22979–22986.
10.1021/acsami.9b05233
CAS PubMed Web of Science® Google Scholar
4Weaver JB, Rauwerdink AM, Sullivan CR, Baker I. Frequency distribution of the nanoparticle magnetization in the presence of a static as well as a harmonic magnetic field. Medical Physics 2008; 35(5): 1988–1994.
10.1118/1.2903449
PubMed Web of Science® Google Scholar
5Kuwahata A, Kaneko M, Chikaki S, Kusakabe M, Sekino M. Development of device for quantifying magnetic nanoparticle tracers accumulating in sentinel lymph nodes. AIP Advances 2018; 8:056713.
10.1063/1.5006668
Web of Science® Google Scholar
6 Kuwahata A, Taruno K, Kurita T, Makita M, Chikaki S, Saito I, Takei H, Nakamura S, Kusakabe M, Sekino M. Magnetic nanoparticle detection by utilizing nonlinear magnetization for sentinel lymph nodes of breast cancer patients. IEEE Transactions on Magnetics 2021; 57:5300404.
10.1109/TMAG.2020.3010641
CAS Web of Science® Google Scholar
7Yoshida T, Ogawa K, Tsubaki T, Othman NB, Enpuku K. Detection of magnetic nanoparticles using the second-harmonic signal. IEEE Transactions on Magnetics 2011; 47(10): 2863–2866.
10.1109/TMAG.2011.2157805
Web of Science® Google Scholar

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Volume17, Issue8

August 2022

Pages 1228-1230

Virus Detection using Second Harmonics of Magnetic Nanoparticles

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