Review
DNA Nanostructures-Based In Situ Cancer Vaccines: Mechanisms and Applications
Bingyu Lin,
Yanfei Liu,
Qiwen Chen,
Mingfeng Li,
Lishang Xu,
Qianqian Chen,
Yifu Tan,
Zhenbao Liu,
Bingyu Lin
Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083 P. R. China
Search for more papers by this authorYanfei Liu
Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083 P. R. China
Search for more papers by this authorQiwen Chen
Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083 P. R. China
Search for more papers by this authorMingfeng Li
Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013 P. R. China
Search for more papers by this authorLishang Xu
Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013 P. R. China
Search for more papers by this authorQianqian Chen
Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083 P. R. China
Search for more papers by this authorYifu Tan
Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013 P. R. China
Search for more papers by this authorCorresponding Author
Zhenbao Liu
Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013 P. R. China
E-mail: [email protected]
Search for more papers by this authorBingyu Lin,
Yanfei Liu,
Qiwen Chen,
Mingfeng Li,
Lishang Xu,
Qianqian Chen,
Yifu Tan,
Zhenbao Liu,
Bingyu Lin
Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083 P. R. China
Search for more papers by this authorYanfei Liu
Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083 P. R. China
Search for more papers by this authorQiwen Chen
Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083 P. R. China
Search for more papers by this authorMingfeng Li
Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013 P. R. China
Search for more papers by this authorLishang Xu
Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013 P. R. China
Search for more papers by this authorQianqian Chen
Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083 P. R. China
Search for more papers by this authorYifu Tan
Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013 P. R. China
Search for more papers by this authorCorresponding Author
Zhenbao Liu
Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013 P. R. China
E-mail: [email protected]
Search for more papers by this authorFirst published: 22 January 2025
Abstract
Current tumor vaccines suffer from inadequate immune responsive due to the insufficient release of tumor antigens, low tumor infiltration, and immunosuppressive microenvironment. DNA nanostructures with their ability to precisely engineer, controlled release, biocompatibility, and the capability to augment the immunogenicity of tumor microenvironment, have gained significant attention for their potential to revolutionize vaccine designing. This review summarizes various applications of DNA nanostructures in the construction of in situ cancer vaccines, which can generate tumor-associated antigens directly from damaged tumors for cancer immune-stimulation. The mechanisms and components of cancer vaccines are listed, the specific strategies for constructing in situ vaccines using DNA nanostructures are explored and their underlying mechanisms of action are elucidated. The immunogenic cell death (ICD) induced by chemotherapeutic agents, photothermal therapy (PTT), photodynamic therapy (PDT), and radiation therapy (RT) and the related cancer vaccines building strategies are systematically summarized. The applications of different DNA nanostructures in various cancer immunotherapy are elaborated, which exerts precise, long-lasting, and robust immune responses. The current challenges and future prospectives are proposed. This review provides a holistic understanding of the evolving role of DNA nanostructures for in situ vaccine development.
Conflict of Interest
The authors declare no conflict of interest.
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