Platinum Nanozyme-Loaded Dissolving Microneedles Scavenge ROS and Promote Lineage Progression for Androgenetic Alopecia Treatment
Weitong Hu
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorShuhan Shi
School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399 China
Search for more papers by this authorYihua Xu
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorYunting Zhang
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorJingyi Hu
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorQiong Bian
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorXiaolu Ma
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorYuxian Ye
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorShengfei Yang
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorXiaoxia Sheng
Hangzhou SoliPharma Co. Ltd, Hangzhou, 311399 China
Search for more papers by this authorGuang Liang
School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399 China
Search for more papers by this authorTianyuan Zhang
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorCorresponding Author
Haibin Wu
School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399 China
E-mail: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Jianqing Gao
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Department of Pharmacy, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009 China
Jiangsu Engineering Research Center for New-type External and Transdermal Preparations, Changzhou, 213149 China
E-mail: [email protected]; [email protected]
Search for more papers by this authorWeitong Hu
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorShuhan Shi
School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399 China
Search for more papers by this authorYihua Xu
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorYunting Zhang
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorJingyi Hu
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorQiong Bian
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorXiaolu Ma
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorYuxian Ye
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorShengfei Yang
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorXiaoxia Sheng
Hangzhou SoliPharma Co. Ltd, Hangzhou, 311399 China
Search for more papers by this authorGuang Liang
School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399 China
Search for more papers by this authorTianyuan Zhang
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Search for more papers by this authorCorresponding Author
Haibin Wu
School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399 China
E-mail: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Jianqing Gao
State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
Department of Pharmacy, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009 China
Jiangsu Engineering Research Center for New-type External and Transdermal Preparations, Changzhou, 213149 China
E-mail: [email protected]; [email protected]
Search for more papers by this authorAbstract
Androgenetic alopecia (AGA) is a prevalent issue affecting the physical and mental health of individuals but with fewer current treatments. Platinum nanozymes (PtNZs) are known for their excellent ability to reduce and modulate the high oxidative stress environment in AGA pathology. And microneedles are used to overcome the skin barrier due to the poor permeability of PtNZs. Herein, dissolving microneedles loaded with PtNZs (Pt-MNs) are designed and successfully induced hair regeneration in the AGA model. Pt-MNs possessed adequate mechanical strength to breach the skin barrier for effective PtNZs delivery. In vivo, PtNZs first reduced reactive oxygen species (ROS) to oxygen, which recovered the AGA pathological environment. And the oxygen then increased oxidative phosphorylation, promoting the differentiation of hair follicle stem cells to achieve hair regeneration. The group treated with Pt-MNs with a dosing frequency of once every three days achieved faster hair growth than the daily application of the positive drug minoxidil. Further safety experiments showed that the application of Pt-MNs locally opened temporary and recoverable skin channels, with no retention of Pt in major organs, indicating high safety. In conclusion, this study indicated the potential of Pt-MNs as an effective method for treating AGA.
Conflict of Interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Supporting Information
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| smtd202401176-sup-0001-SuppMat.docx2.2 MB | Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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