Landscape of Cell Communication in Human Dental Pulp
Wei Yin
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079 China
Search for more papers by this authorGaoxia Liu
Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 China
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, 430022 China
Search for more papers by this authorJinhong Li
Department of Stomatology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, 310007 China
Search for more papers by this authorCorresponding Author
Zhuan Bian
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079 China
E-mail: [email protected]
Search for more papers by this authorWei Yin
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079 China
Search for more papers by this authorGaoxia Liu
Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 China
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, 430022 China
Search for more papers by this authorJinhong Li
Department of Stomatology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, 310007 China
Search for more papers by this authorCorresponding Author
Zhuan Bian
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079 China
E-mail: [email protected]
Search for more papers by this authorAbstract
The cellular atlas of the stroma is not well understood. Here, the cell populations in human dental pulp through single-cell RNA sequencing are profiled. Dental pulp stem cells, pulp cells, T cells, macrophages, endothelial cells, and glial cells are identified in human dental pulp. These cells support each other through sending growth signals. Based on the appearance of ligand–receptor pairs between two cell populations, pulp cells have the greatest communication with other cell types, while T cells have the least communication. In addition, T cells expressing TLR1, TLR2, and TLR4, and endothelial cells expressing TLR4, monitor bacterial invasion. These findings provide the census of normal dental pulp.
Conflict of Interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The single cell sequencing data generated during this study are deposited in GEO (GSE167251, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc = GSE167251).
Supporting Information
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