Deep Tumor Penetrating Gold Nano-Adjuvant for NIR-II-Triggered In Situ Tumor Vaccination
Anhong Chen
Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, 518107 P. R. China
Search for more papers by this authorLei Wu
Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, 518107 P. R. China
Search for more papers by this authorYao Luo
Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, 518107 P. R. China
Search for more papers by this authorShaojin Lu
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022 P. R. China
Search for more papers by this authorYupeng Wang
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515 P. R. China
Search for more papers by this authorZhengzheng Zhou
NMPA Key Laboratory for Safety Evaluation of Cosmetics, Department of Hygiene Inspection & Quarantine Science, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515 China
Search for more papers by this authorCorresponding Author
Dongfang Zhou
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Zhigang Xie
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Jun Yue
Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, 518107 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorAnhong Chen
Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, 518107 P. R. China
Search for more papers by this authorLei Wu
Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, 518107 P. R. China
Search for more papers by this authorYao Luo
Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, 518107 P. R. China
Search for more papers by this authorShaojin Lu
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022 P. R. China
Search for more papers by this authorYupeng Wang
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515 P. R. China
Search for more papers by this authorZhengzheng Zhou
NMPA Key Laboratory for Safety Evaluation of Cosmetics, Department of Hygiene Inspection & Quarantine Science, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515 China
Search for more papers by this authorCorresponding Author
Dongfang Zhou
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Zhigang Xie
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Jun Yue
Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, 518107 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorAbstract
Local tumor photothermal treatment with the near-infrared light at the second window (NIR-II) is a promising strategy in triggering the in situ tumor vaccination (ISTV) for cancer therapy. However, limited penetration of photothermal agents within tumors seriously limits their spatial effect in generating sufficient tumor-associated antigens, a key factor to the success of ISTV. In this study, a nano-adjuvant system is fabricated based on the NIR-II-absorbable gold nanostars decorated with hyaluronidases and immunostimulatory oligodeoxynucleotides CpG for ISTV. The nano-adjuvant displays a deep tumor penetration capacity via loosening the dense extracellular matrix of tumors. Upon NIR-II light irradiation, the nano-adjuvant significantly inhibits the tumor growth, induces a cascade of immune responses, generates an obvious adaptive immunity against the re-challenged cancers, boosts the abscopal effect, and completely inhibits the pulmonary metastases. The study highlights an advanced nano-adjuvant formulation featuring deep tumor penetration for NIR-II-triggered ISTV.
Conflict of Interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
| Filename | Description |
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| smll202200993-sup-0001-SuppMat.pdf2.7 MB | Supporting information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
References
- 1E. Blass, P. A. Ott, Nat. Rev. Clin. Oncol. 2021, 18, 215.
- 2U. Sahin, Ö. Türeci, Science 2018, 359, 1355.
- 3C. S. Shemesh, J. C. Hsu, I. Hosseini, B.-Q. Shen, A. Rotte, P. Twomey, S. Girish, B. Wu, Mol. Ther. 2021, 29, 555.
- 4Z. Hu, P. A. Ott, C. J. Wu, Nat. Rev. Immunol. 2018, 18, 168.
- 5P. A. Ott, Z. Hu, D. B. Keskin, S. A. Shukla, J. Sun, D. J. Bozym, W. Zhang, A. Luoma, A. Giobbie-Hurder, L. Peter, C. Chen, O. Olive, T. A. Carter, S. Li, D. J. Lieb, T. Eisenhaure, E. Gjini, J. Stevens, W. J. Lane, I. Javeri, K. Nellaiappan, A. M. Salazar, H. Daley, M. Seaman, E. I. Buchbinder, C. H. Yoon, M. Harden, N. Lennon, S. Gabriel, S. J. Rodig, et al., Nature 2017, 547, 217.
- 6U. Sahin, E. Derhovanessian, M. Miller, B.-P. Kloke, P. Simon, M. Löwer, V. Bukur, A. D. Tadmor, U. Luxemburger, B. Schrörs, T. Omokoko, M. Vormehr, C. Albrecht, A. Paruzynski, A. N. Kuhn, J. Buck, S. Heesch, K. H. Schreeb, F. Müller, I. Ortseifer, I. Vogler, E. Godehardt, S. Attig, R. Rae, A. Breitkreuz, C. Tolliver, M. Suchan, G. Martic, A. Hohberger, P. Sorn, et al., Nature 2017, 547, 222.
- 7W. Ngamcherdtrakul, M. Reda, M. A. Nelson, R. J. Wang, H. Y. Zaidan, D. S. Bejan, N. H. Hoang, R. S. Lane, S. W. Luoh, S. A. Leachman, G. B. Mills, J. W. Gray, A. W. Lund, W. Yantasee, Adv. Mater. 2021, 33, 2100628.
- 8X. Liu, Q. Su, H. J. Song, X. G. Shi, Y. M. Zhang, C. N. Zhang, P. S. Huang, A. J. Dong, D. L. Kong, W. W. Wang, Biomaterials 2021, 275, 120921.
- 9Y. Y. Hu, L. Lin, Z. P. Guo, J. Chen, A. Maruyama, H. Y. Tian, X. S. Chen, Chin. Chem. Lett. 2021, 32, 1770.
- 10H. W. Li, J. Y. Yu, Y. Y. Wu, B. Shao, X. W. Wei, J. Cell. Physiol. 2020, 235, 5490.
- 11L. T. Gray, D. S. Wilson, J. Ishihara, K. Sasaki, M. Raczy, M. Swartz, J. Hubbell, Cancer Res. 2020, 80, 4582.
- 12C. Wang, N. F. Steinmetz, Adv. Healthcare Mater. 2019, 8, 1801288.
- 13T. Marchell, D. Wilson, A. Alpar, J. Hubbell, J Immunother. Cancer 2019, 7, P674.
- 14L. Hammerich, T. U. Marron, R. Upadhyay, J. Svensson-Arvelund, M. Dhainaut, S. Hussein, Y. G. Zhan, D. Ostrowski, M. Yellin, H. Marsh, A. M. Salazar, A. H. Rahman, B. D. Brown, M. Merad, J. D. Brody, Nat. Med. 2019, 25, 814.
- 15L. Hammerich, A. Binder, J. D. Brody, Mol. Oncol. 2015, 9, 1966.
- 16B. Chen, L. Mei, R. R. Fan, Y. L. Wang, C. L. Nie, A. P. Tong, G. Guo, Chin. Chem. Lett. 2021, 32, 1775.
- 17Y. Q. Chen, M. N. Jiang, L. W. Xiong, X. X. Yao, M. J. Fan, D. Y. Chen, Q. Jiang, Z. K. Jin, Q. J. He, Chin. Chem. Lett. 2021, 32, 3487.
- 18Z. J. Cheng, T. Zhang, W. L. Wang, Q. Shen, Y. Hong, J. J. Shao, X. J. Xie, Z. H. Fei, X. C. Dong, Chin. Chem. Lett. 2021, 32, 1580.
- 19L. R. Zhang, J. J. Zhang, L. X. Xu, Z. J. Zhuang, J. J. Liu, S. W. Liu, Y. C. Wu, A. H. Gong, M. M. Zhang, F. Y. Du, J. Nanobiotechnol. 2021, 19, 142.
- 20G. Hong, A. L. Antaris, H. Dai, Nat. Biomed. Eng. 2017, 1, 0010.
- 21C. Xu, K. Pu, Chem. Soc. Rev. 2021, 50, 1111.
- 22H. M. Dai, Z. J. Cheng, T. Zhang, W. L. Wang, J. J. Shao, W. J. Wang, Y. X. Zhao, X. C. Dong, L. P. Zhong, Chin. Chem. Lett. 2021, https://doi.org/10.1016/j.cclet.2021.11.079.
- 23C. Xie, W. Zhou, Z. Zeng, Q. Fan, K. Pu, Chem. Sci. 2020, 11, 10553.
- 24Y. Yang, X. Fan, L. Li, Y. Yang, A. Nuernisha, D. Xue, C. He, J. Qian, Q. Hu, H. Chen, J. Liu, W. Huang, ACS Nano 2020, 14, 2509.
- 25Z. Cao, L. Feng, G. Zhang, J. Wang, S. Shen, D. Li, X. Yang, Biomaterials 2018, 155, 103.
- 26Y. Zhang, Q. Shen, Q. Li, P. P. He, J. Y. Li, F. Huang, J. Wang, Y. F. Duan, C. Shen, A. S. Saleem, Z. M. Luo, L. H. Wang, Adv. Sci. 2021, 8, 2100386.
- 27H. C. Duan, H. Y. Guo, R. F. Zhang, F. F. Wang, Z. Liu, M. Ge, L. D. Yu, H. Lin, Y. Chen, Biomaterials 2020, 256, 120206.
- 28S. Q. Sun, Y. P. Song, J. B. Chen, M. F. Huo, Y. Chen, L. N. Sun, Nanoscale 2021, 13, 18300.
- 29M. Wen, J. Ouyang, C. Wei, H. Li, W. Chen, Y.-N. Liu, Angew. Chem., Int. Ed. 2019, 58, 17425.
- 30X. Wang, X. Zhong, H. Lei, Y. Geng, Q. Zhao, F. Gong, Z. Yang, Z. Dong, Z. Liu, L. Cheng, Chem. Mater. 2019, 31, 6174.
- 31N. Li, P. X. Zhao, D. Astruc, Angew. Chem., Int. Ed. 2014, 53, 1756.
- 32A. Oladipo, T. C. Lebepe, S. Parani, R. Maluleke, V. Ncapayi, G. I. Mbaz, S. P. Songca, T. Kodama, O. S. Oluwafemi, Pharmaceuticals 2021, 14, 1137.
- 33S. B. Zhao, Y. Q. Luo, Z. Chang, C. C. Liu, T. Li, L. Gan, Y. Huang, Q. C. Sun, Nanoscale Res. Lett. 2021, 16, 170.
- 34Y. Zhang, T. Song, T. Feng, Y. Wan, N. T. Blum, C. Liu, C. Zheng, Z. Zhao, T. Jiang, J. Wang, Q. Li, J. Lin, L. Tang, P. Huang, Nano Today 2020, 35, 100987.
- 35S. Cui, S. Fan, H. Tan, Y. Lu, Y. Zha, B. Xu, Y. Liu, D. Cui, Nanoscale 2021, 13, 15569.
- 36Y. Liu, Y. Pan, W. Cao, F. Xia, B. Liu, J. Niu, G. Alfranca, X. Sun, L. Ma, J. M. d. l. Fuente, J. Song, J. Ni, D. Cui, Theranostics 2019, 9, 6867.
- 37C. Zhang, C. Li, Y. Liu, J. Zhang, C. Bao, S. Liang, Q. Wang, Y. Yang, H. Fu, K. Wang, D. Cui, Adv. Funct. Mater. 2015, 25, 1314.
- 38K. Lee, Z. N. Huang, C. A. Mirkin, T. W. Odom, Nano Lett. 2020, 20, 6170.
- 39D. Bhowmik, K. S. B. Culver, T. Liu, T. W. Odom, ACS Nano 2019, 13, 13637.
- 40K. Chandra, K. S. B. Culver, S. E. Werner, R. C. Lee, T. W. Odom, Chem. Mater. 2016, 28, 6763.
- 41V. P. Chauhan, T. Stylianopoulos, Y. Boucher, R. K. Jain, Annu. Rev. Chem. Biomol. Eng. 2011, 2, 281.
- 42X. Ye, T. Feng, L. Li, T. Wang, P. Li, W. Huang, Acta Biomater. 2021, 125, 29.
- 43F. Puleo, R. Nicolle, Y. Blum, J. Cros, L. Marisa, P. Demetter, E. Quertinmont, M. Svrcek, N. Elarouci, J. Iovanna, D. Franchimont, L. Verset, M. G. Galdon, J. Devière, A. de Reyniès, P. Laurent-Puig, J.-L. Van Laethem, J.-B. Bachet, R. Maréchal, Gastroenterology 2018, 155, 1999.e3.
- 44J. Vollmer, A. M. Krieg, Adv Drug Deliver Rev 2009, 61, 195.
- 45D. M. Klinman, Nat. Rev. Immunol. 2004, 4, 249.
- 46C. H. J. Choi, L. L. Hao, S. P. Narayan, E. Auyeung, C. A. Mirkin, Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 7625.
- 47P. C. Patel, D. A. Giljohann, W. L. Daniel, D. Zheng, A. E. Prigodich, C. A. Mirkin, Bioconjugate Chem. 2010, 21, 2250.
- 48R. Foty, J. Visualized Exp. 2011, 51, e2720.
- 49W. W. Liu, P. C. Li, J. Biomed. Sci. 2020, 27, 3.
- 50A. E. R. Kartikasari, M. D. Prakash, M. Cox, K. Wilson, J. C. Boer, J. A. Cauchi, M. Plebanski, Front. Immunol. 2019, 9, 3109.
- 51N. Zhang, Z. M. Zhang, X. F. Wang, Eur. J. Inflammation 2021, 19, 20587392211047644.
- 52M. E. Wechsler, A. Munitz, S. J. Ackerman, M. G. Drake, D. J. Jackson, A. J. Wardlaw, S. K. Dougan, S. Berdnikovs, F. Schleich, A. Matucci, P. Chanez, C. M. Prazma, P. Howarth, P. F. Weller, P. A. Merkel, Mayo Clin. Proc. 2021, 96, 2694.
- 53M. Ramos-Casals, A. Flores-Chavez, P. Brito-Zeron, Pol. Arch. Intern. Med. 2021, 131, 16092.
- 54G. M. Hu, S. M. Wang, K. F. Zhong, F. Xu, L. M. Huang, W. Chen, P. Cheng, BMC Cancer 2020, 20, 454.
- 55S. Grisaru-Tal, M. Itan, A. D. Klion, A. Munitz, Nat. Rev. Cancer 2020, 20, 594.
- 56S. Sakkal, S. Miller, V. Apostolopoulos, K. Nurgali, Curr. Med. Chem. 2016, 23, 650.
- 57H. J. Bax, J. Chauhan, C. Stavraka, A. Khiabany, M. Nakamura, G. Pellizzari, K. M. Ilieva, S. Lombardi, H. J. Gould, C. J. Corrigan, S. J. Till, S. Katugampola, P. S. Jones, C. Barton, A. Winship, S. Ghosh, A. Montes, D. H. Josephs, J. F. Spicer, S. N. Karagiannis, Cells-Basel 2020, 9, 1631.
- 58I. M. Sektioglu, R. Carretero, N. Bulbuc, T. Bald, T. Tuting, A. Y. Rudensky, G. J. Hammerling, Cancer Res. 2017, 77, 291.
- 59W. Ngwa, O. C. Irabor, J. D. Schoenfeld, J. Hesser, S. Demaria, S. C. Formenti, Nat. Rev. Cancer 2018, 18, 313.
