Volume 2, Issue 10 pp. 1139-1143

Communication

Apoferritin-Templated Synthesis of Metal Phosphate Nanoparticle Labels for Electrochemical Immunoassay^†

Guodong Liu Dr.,

Guodong Liu Dr.

Pacific Northwest National Laboratory, Richland, WA 99352, USA, Fax: (+1) 509-376-5106

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Hong Wu,

Hong Wu

Pacific Northwest National Laboratory, Richland, WA 99352, USA, Fax: (+1) 509-376-5106

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Jun Wang Dr.,

Jun Wang Dr.

Pacific Northwest National Laboratory, Richland, WA 99352, USA, Fax: (+1) 509-376-5106

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Yuehe Lin Dr.,

Yuehe Lin Dr.

[email protected]

Pacific Northwest National Laboratory, Richland, WA 99352, USA, Fax: (+1) 509-376-5106

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Guodong Liu Dr.,

Guodong Liu Dr.

Pacific Northwest National Laboratory, Richland, WA 99352, USA, Fax: (+1) 509-376-5106

Search for more papers by this author

Hong Wu,

Hong Wu

Pacific Northwest National Laboratory, Richland, WA 99352, USA, Fax: (+1) 509-376-5106

Search for more papers by this author

Jun Wang Dr.,

Jun Wang Dr.

Pacific Northwest National Laboratory, Richland, WA 99352, USA, Fax: (+1) 509-376-5106

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Yuehe Lin Dr.,

Yuehe Lin Dr.

[email protected]

Pacific Northwest National Laboratory, Richland, WA 99352, USA, Fax: (+1) 509-376-5106

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First published: 29 August 2006

https://doi.org/10.1002/smll.200600206

Citations: 66

^†

This work is supported by the U.S. Department of Energy’s (DOEs) Laboratory Directed Research and Development program. The research described in this paper was performed at the Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by the DOEs Office of Biological and Environmental Research and located at Pacific Northwest National Laboratory, which is operated by Battelle for DOE under contract DE-AC05-76L01830. The authors would like to thank Dr. Chongming Wang for help with transmission electron microscopy imaging and Mr. Wayne Cosby for editing the manuscript.

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Graphical Abstract

Targeting proteins: Metal phosphate nanoparticles (see scheme; NHS-biotin=biotinamidohexanoyl-6-amino-hexanoic acid N-hydroxy-succinimide ester) based on an apoferritin template have been synthesized and used as biological labels for electrochemical immunoassay. The template offers a simple and convenient route for the preparation of metallic nanoparticle labels under mild conditions. The assay method is ultrasensitive (detection limit as low as 77 fm); simultaneous detection of multiple protein targets can be performed by using different labels.

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Volume2, Issue10

October 2006

Pages 1139-1143

Apoferritin-Templated Synthesis of Metal Phosphate Nanoparticle Labels for Electrochemical Immunoassay^†

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Apoferritin-Templated Synthesis of Metal Phosphate Nanoparticle Labels for Electrochemical Immunoassay†

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Apoferritin-Templated Synthesis of Metal Phosphate Nanoparticle Labels for Electrochemical Immunoassay^†