Curcumin nanomicelle improves semen parameters, oxidative stress, inflammatory biomarkers, and reproductive hormones in infertile men: A randomized clinical trial
Fatemeh Alizadeh
Department of Nutrition, School of Health, Qazvin University of Medical Science, Qazvin, Iran
Search for more papers by this authorMaryam Javadi
Department of Nutrition, School of Health, Qazvin University of Medical Science, Qazvin, Iran
Search for more papers by this authorAli Akbar Karami
Department of Urology, Velayat Hospital, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
Search for more papers by this authorFereshteh Gholaminejad
Department of Nutrition, School of Health, Qazvin University of Medical Science, Qazvin, Iran
Search for more papers by this authorMaria Kavianpour
Department of Tissue Engineering and Applied Cell Sciences, Faculty of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorCorresponding Author
Hossein Khadem Haghighian
Department of Nutrition, School of Health, Qazvin University of Medical Science, Qazvin, Iran
Correspondence
Hossein Khadem Haghighian, Department of Nutrition, Faculty of Health, Qazvin University of Medical Sciences Qazvin, Iran.
Email: [email protected]
Search for more papers by this authorFatemeh Alizadeh
Department of Nutrition, School of Health, Qazvin University of Medical Science, Qazvin, Iran
Search for more papers by this authorMaryam Javadi
Department of Nutrition, School of Health, Qazvin University of Medical Science, Qazvin, Iran
Search for more papers by this authorAli Akbar Karami
Department of Urology, Velayat Hospital, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
Search for more papers by this authorFereshteh Gholaminejad
Department of Nutrition, School of Health, Qazvin University of Medical Science, Qazvin, Iran
Search for more papers by this authorMaria Kavianpour
Department of Tissue Engineering and Applied Cell Sciences, Faculty of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorCorresponding Author
Hossein Khadem Haghighian
Department of Nutrition, School of Health, Qazvin University of Medical Science, Qazvin, Iran
Correspondence
Hossein Khadem Haghighian, Department of Nutrition, Faculty of Health, Qazvin University of Medical Sciences Qazvin, Iran.
Email: [email protected]
Search for more papers by this authorAbstract
At least 50% of infertile couple's problems are related to male factor infertility. This Randomized, Double-Blind, Placebo-Controlled Clinical Trial conducted in Urology unit of Infertility Clinic on 60 infertile men. Patients were randomly assigned to one of intervention and placebo (n = 30) groups. Finally, 28 subjects in each group completed the study. Participants in the intervention group took daily 80 mg curcumin nanomicelle and those in the placebo group took daily placebo for 10 weeks. Semen analysis, anthropometric, physical activity assessments, total antioxidant capacity, malondialdehyde, inflammatory factors, and reproductive hormones were measured at the baseline and at the end of the study. At the end of study, statistically significant differences were seen in the total sperm count, sperm concentration, and motility in the intervention group to the control group. In treatment group, the total sperm count, sperm concentration, and motility levels were also statistically increased at the end of study compared to the baseline values. Curcumin nanomicelle supplementation also resulted in a statistically significant improvement in plasma levels of total antioxidant capacity, malondialdehyde, C-reactive protein, and tumor necrosis factor a in comparison to the placebo. Medical therapy of asthenoteratospermia with curcumin nanomicelle supplement could improve quality of semen parameters. However, further investigation is suggested in this regard.
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