Digallic acid from Pistascia lentiscus fruits induces apoptosis and enhances antioxidant activities
Wissem Bhouri
Laboratoire de biologie Cellulaire et Moléculaire Faculté de Medecine Dentaire Monastir, Rue Avicenne, 5000 Tunisia
Unité de pharmacognosie 99/UR/07 Faculté de pharmacie Monastir, Rue Avicenne, 5000 Tunisia
Search for more papers by this authorInes Skandrani
Laboratoire de biologie Cellulaire et Moléculaire Faculté de Medecine Dentaire Monastir, Rue Avicenne, 5000 Tunisia
Unité de pharmacognosie 99/UR/07 Faculté de pharmacie Monastir, Rue Avicenne, 5000 Tunisia
Search for more papers by this authorMohamed ben Sghair
Laboratoire de biologie Cellulaire et Moléculaire Faculté de Medecine Dentaire Monastir, Rue Avicenne, 5000 Tunisia
Unité de pharmacognosie 99/UR/07 Faculté de pharmacie Monastir, Rue Avicenne, 5000 Tunisia
Search for more papers by this authorMarie-Geneviève Djoux Franca
Département de Pharmaco-chimie Moléculaire, UMR 5063 CNRS-UJF, UFR de Pharmacie de Grenoble, Domaine de la Merci, 38706 La Tronche Cedex, France
Search for more papers by this authorKamel Ghedira
Unité de pharmacognosie 99/UR/07 Faculté de pharmacie Monastir, Rue Avicenne, 5000 Tunisia
Search for more papers by this authorCorresponding Author
Leila Chekir Ghedira
Laboratoire de biologie Cellulaire et Moléculaire Faculté de Medecine Dentaire Monastir, Rue Avicenne, 5000 Tunisia
Unité de pharmacognosie 99/UR/07 Faculté de pharmacie Monastir, Rue Avicenne, 5000 Tunisia
Leila Chekir-Ghedira, Faculty of Dental Medicine, Rue Avicenne 5019 Monastir, Tunisia.
E-mail: [email protected]
Search for more papers by this authorWissem Bhouri
Laboratoire de biologie Cellulaire et Moléculaire Faculté de Medecine Dentaire Monastir, Rue Avicenne, 5000 Tunisia
Unité de pharmacognosie 99/UR/07 Faculté de pharmacie Monastir, Rue Avicenne, 5000 Tunisia
Search for more papers by this authorInes Skandrani
Laboratoire de biologie Cellulaire et Moléculaire Faculté de Medecine Dentaire Monastir, Rue Avicenne, 5000 Tunisia
Unité de pharmacognosie 99/UR/07 Faculté de pharmacie Monastir, Rue Avicenne, 5000 Tunisia
Search for more papers by this authorMohamed ben Sghair
Laboratoire de biologie Cellulaire et Moléculaire Faculté de Medecine Dentaire Monastir, Rue Avicenne, 5000 Tunisia
Unité de pharmacognosie 99/UR/07 Faculté de pharmacie Monastir, Rue Avicenne, 5000 Tunisia
Search for more papers by this authorMarie-Geneviève Djoux Franca
Département de Pharmaco-chimie Moléculaire, UMR 5063 CNRS-UJF, UFR de Pharmacie de Grenoble, Domaine de la Merci, 38706 La Tronche Cedex, France
Search for more papers by this authorKamel Ghedira
Unité de pharmacognosie 99/UR/07 Faculté de pharmacie Monastir, Rue Avicenne, 5000 Tunisia
Search for more papers by this authorCorresponding Author
Leila Chekir Ghedira
Laboratoire de biologie Cellulaire et Moléculaire Faculté de Medecine Dentaire Monastir, Rue Avicenne, 5000 Tunisia
Unité de pharmacognosie 99/UR/07 Faculté de pharmacie Monastir, Rue Avicenne, 5000 Tunisia
Leila Chekir-Ghedira, Faculty of Dental Medicine, Rue Avicenne 5019 Monastir, Tunisia.
E-mail: [email protected]
Search for more papers by this authorAbstract
The antioxidant and apoptotic activities of digallic acid, isolated from the fruits of Pistascia lentiscus, were investigated. The study demonstrated that digallic acid possessed pro-apoptotic effects, as shown by provoking DNA fragmentation of K562 cells. It also revealed a significant antioxidant potential and effective scavenging activity against 2,2-diphenyl-1-picrylhdrazyl (DPPH·) and O2·− radicals, and reduced cupric ions. We conclude that this integrated approach to apoptotic and antioxidant assessment may be useful to maximize the beneficial effects associated with using P. lentiscus derivatives as medicinal and dietary compounds. Copyright © 2011 John Wiley & Sons, Ltd.
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