Renoprotective effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, on rats with chronic kidney disease
Young-Min Ahn
Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul 130-702, Republic of Korea
These authors contributed equally to this article.
Search for more papers by this authorSu Kang Kim
Kohwang Medical Research Institute, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul, 130-701, Republic of Korea
These authors contributed equally to this article.
Search for more papers by this authorSang-Hun Lee
Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul 130-702, Republic of Korea
Search for more papers by this authorSe-Young Ahn
Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul 130-702, Republic of Korea
Search for more papers by this authorSung Wook Kang
Kohwang Medical Research Institute, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul, 130-701, Republic of Korea
Search for more papers by this authorJoo-Ho Chung
Kohwang Medical Research Institute, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul, 130-701, Republic of Korea
Search for more papers by this authorSung-Do Kim
Department of Pediatrics, East West Kidney Diseases Research Institute, Kyung-Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul 130-702, Republic of Korea
Search for more papers by this authorCorresponding Author
Byung-Cheol Lee
Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul 130-702, Republic of Korea
Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Republic of KoreaSearch for more papers by this authorYoung-Min Ahn
Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul 130-702, Republic of Korea
These authors contributed equally to this article.
Search for more papers by this authorSu Kang Kim
Kohwang Medical Research Institute, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul, 130-701, Republic of Korea
These authors contributed equally to this article.
Search for more papers by this authorSang-Hun Lee
Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul 130-702, Republic of Korea
Search for more papers by this authorSe-Young Ahn
Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul 130-702, Republic of Korea
Search for more papers by this authorSung Wook Kang
Kohwang Medical Research Institute, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul, 130-701, Republic of Korea
Search for more papers by this authorJoo-Ho Chung
Kohwang Medical Research Institute, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul, 130-701, Republic of Korea
Search for more papers by this authorSung-Do Kim
Department of Pediatrics, East West Kidney Diseases Research Institute, Kyung-Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul 130-702, Republic of Korea
Search for more papers by this authorCorresponding Author
Byung-Cheol Lee
Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul 130-702, Republic of Korea
Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Republic of KoreaSearch for more papers by this authorAbstract
Chronic kidney disease (CKD) is a common cause of end-stage renal disease. Antihypertensive agents are used clinically to inhibit the progression of CKD, but cannot prevent eventual renal failure. This study investigated the effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, in rats suffering from CKD induced by 5/6 nephrectomy. After development of renal insufficiency, the rats were treated with Tanshinone IIA (10 mg/kg) for 8 weeks. Serum creatinine, angiotensin II (Ang II), transforming growth factor β1 (TGF-β1) and collagen IV levels were significantly reduced in Tanshinone IIA treated rats compared with a control group. In addition, Tanshinone IIA suppressed increases in urinary protein excretion in CKD rats. These findings suggest that chronic oral administration of Tanshinone IIA can improve renal dysfunction associated with CKD. Copyright © 2010 John Wiley & Sons, Ltd.
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