ORIGINAL ARTICLE

Esophageal impedance baseline in infants with bronchopulmonary dysplasia: A pilot study

Corresponding Author

Stefano Nobile MD, PhD

[email protected]

orcid.org/0000-0002-5304-1485

Department of Woman, Child and Public Health, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy

Correspondence Stefano Nobile, Neonatal Unit, Fondazione Policinico Universitario “A. Gemelli” IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy.

Email: [email protected]

Contribution: Conceptualization (lead), Data curation (equal), Formal analysis (lead), Methodology (lead), Writing - review & editing (lead)

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Paolo Marchionni PhD,

Paolo Marchionni PhD

orcid.org/0000-0002-5141-7725

Clinical Engineering Unit, Azienda Sanitaria Unica Regionale Marche, Civitanova Alta, Italy

Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal)

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Fabio Meneghin MD,

Fabio Meneghin MD

Neonatal Unit, Buzzi Children's Hospital, ASST-FBF-Sacco, Milan, Italy

Contribution: Data curation (equal), Formal analysis (equal), Writing - original draft (supporting)

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Silvia Salvatore MD, PhD,

Silvia Salvatore MD, PhD

Department of Pediatrics, Ospedale F. Del Ponte, ASST-Sette Laghi, Università dell'Insubria, Varese, Italy

Contribution: Data curation (equal), Formal analysis (equal), Methodology (equal), Writing - review & editing (equal)

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Carmine Noviello MD,

Carmine Noviello MD

Department of Mother and Child Health, Salesi Children's Hospital, Ancona, Italy

Department of Woman, Child, General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Caserta, Italy

Contribution: Data curation (supporting), Formal analysis (supporting), Investigation (equal), Writing - original draft (supporting)

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Gaia Margiotta MD,

Gaia Margiotta MD

Department of Woman, Child and Public Health, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy

Contribution: Data curation (supporting), Investigation (supporting), Writing - original draft (supporting)

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Valentina Giorgio MD,

Valentina Giorgio MD

Department of Woman, Child and Public Health, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy

Contribution: Data curation (supporting), Formal analysis (supporting), Investigation (equal), Writing - original draft (supporting)

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Giovanni Vento MD, PhD,

Giovanni Vento MD, PhD

orcid.org/0000-0003-3121-9569

Department of Woman, Child and Public Health, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy

Contribution: Data curation (equal), Investigation (supporting), Methodology (equal), Supervision (equal), Writing - review & editing (equal)

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Stefano Nobile MD, PhD,

Corresponding Author

Stefano Nobile MD, PhD

[email protected]

orcid.org/0000-0002-5304-1485

Department of Woman, Child and Public Health, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy

Correspondence Stefano Nobile, Neonatal Unit, Fondazione Policinico Universitario “A. Gemelli” IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy.

Email: [email protected]

Contribution: Conceptualization (lead), Data curation (equal), Formal analysis (lead), Methodology (lead), Writing - review & editing (lead)

Search for more papers by this author

Paolo Marchionni PhD,

Paolo Marchionni PhD

orcid.org/0000-0002-5141-7725

Clinical Engineering Unit, Azienda Sanitaria Unica Regionale Marche, Civitanova Alta, Italy

Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal)

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Fabio Meneghin MD,

Fabio Meneghin MD

Neonatal Unit, Buzzi Children's Hospital, ASST-FBF-Sacco, Milan, Italy

Contribution: Data curation (equal), Formal analysis (equal), Writing - original draft (supporting)

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Silvia Salvatore MD, PhD,

Silvia Salvatore MD, PhD

Department of Pediatrics, Ospedale F. Del Ponte, ASST-Sette Laghi, Università dell'Insubria, Varese, Italy

Contribution: Data curation (equal), Formal analysis (equal), Methodology (equal), Writing - review & editing (equal)

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Carmine Noviello MD,

Carmine Noviello MD

Department of Mother and Child Health, Salesi Children's Hospital, Ancona, Italy

Department of Woman, Child, General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Caserta, Italy

Contribution: Data curation (supporting), Formal analysis (supporting), Investigation (equal), Writing - original draft (supporting)

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Gaia Margiotta MD,

Gaia Margiotta MD

Department of Woman, Child and Public Health, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy

Contribution: Data curation (supporting), Investigation (supporting), Writing - original draft (supporting)

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Valentina Giorgio MD,

Valentina Giorgio MD

Department of Woman, Child and Public Health, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy

Contribution: Data curation (supporting), Formal analysis (supporting), Investigation (equal), Writing - original draft (supporting)

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Giovanni Vento MD, PhD,

Giovanni Vento MD, PhD

orcid.org/0000-0003-3121-9569

Department of Woman, Child and Public Health, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy

Contribution: Data curation (equal), Investigation (supporting), Methodology (equal), Supervision (equal), Writing - review & editing (equal)

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First published: 15 November 2021

https://doi.org/10.1002/ppul.25758

Citations: 2

Preliminary results of this study were presented as a poster at the European Academy of Pediatric Societies (EAPS) Congress, virtual edition, October 16–19, 2020.

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Abstract

Background

Bronchopulmonary dysplasia (BPD) may induce gastroesophageal reflux (GER). Esophageal impedance baseline values (BI) reflect mucosal inflammation. Our aim was to evaluate BI levels in preterm infants with BPD compared with those without BPD and to identify BI predictors.

Methods

This is a retrospective pilot study including infants born <32 weeks' gestational age (GA) who underwent esophageal multichannel intraluminal impedance (MII)-pH. Univariate/multivariate analysis were performed to compare data between BPD and non-BPD infants and to identify BI predictors. A subgroup analysis was performed in infants born <29 weeks' GA, at highest risk for BPD.

Results

Ninety-seven patients (median GA 28^5/7 weeks, mean postnatal age 49 days, 29 with BPD), were studied. BPD infants had significantly lower birth weight compared with non-BPD infants (750 vs. 1275 g), were more immature (27^4/7 vs. 29^0/7 weeks GA), were older at MII-pH (79 vs. 38 days) and received less fluids during MII-pH (147 vs. 161 ml/kg/day). The same findings were found in the group of 53 infants born <29 weeks. BPD versus non-BPD infants had significantly lower BI (2050 vs. 2574 ohm, p = 0.007) (<1000 ohm in five BPD infants vs. one non-BPD) whereas the other MII-pH parameters were not significantly different. Multiple regression analysis found that increasing chronological age was positively associated with BI (B = 9.3, p = 0.013) whereas BPD was associated with lower BI (B = −793.4, p < 0.001).

Conclusions

BPD versus non-BPD infants had significantly lower BI despite similar MII-pH data. BPD and chronological age predicted BI, whereas only BPD predicted BI in the most immature infants.

CONFLICT OF INTERESTS

The authors declare that there are no conflict of interests.

Open Research

DATA AVAILABILITY STATEMENT

Data will be available upon request.

REFERENCES

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Volume57, Issue2

February 2022

Pages 448-454

Esophageal impedance baseline in infants with bronchopulmonary dysplasia: A pilot study

Abstract

Background

Methods

Results

Conclusions

CONFLICT OF INTERESTS

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

Information

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Esophageal impedance baseline in infants with bronchopulmonary dysplasia: A pilot study

Abstract

Background

Methods

Results

Conclusions

CONFLICT OF INTERESTS

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

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