Evaluation of interrupter resistance in methacholine challenge testing in children
Corresponding Author
Marije Koopman MD
Department of Paediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands
Department of Paediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Huispostnummer KH.01.419.0, PO Box 85090, 3508 AB Utrecht, the Netherlands.Search for more papers by this authorHein J.L. Brackel MD, PhD
Department of Paediatrics, Catharina Hospital, Eindhoven, the Netherlands
Search for more papers by this authorAnja A.P.H. Vaessen-Verberne MD, PhD
Department of Paediatrics, Amphia Hospital, Breda, the Netherlands
Search for more papers by this authorWim C. Hop PhD
Department of Biostatistics, Erasmus MC, University Medical, Centre Rotterdam, Rotterdam, the Netherlands
Search for more papers by this authorCornelis K. van der Ent MD, PhD
Department of Paediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands
Search for more papers by this authoron behalf of the COMBO-Rint Research Group
COMBO-Rint Research Group members are listed in the Acknowledgment Section.
Search for more papers by this authorCorresponding Author
Marije Koopman MD
Department of Paediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands
Department of Paediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Huispostnummer KH.01.419.0, PO Box 85090, 3508 AB Utrecht, the Netherlands.Search for more papers by this authorHein J.L. Brackel MD, PhD
Department of Paediatrics, Catharina Hospital, Eindhoven, the Netherlands
Search for more papers by this authorAnja A.P.H. Vaessen-Verberne MD, PhD
Department of Paediatrics, Amphia Hospital, Breda, the Netherlands
Search for more papers by this authorWim C. Hop PhD
Department of Biostatistics, Erasmus MC, University Medical, Centre Rotterdam, Rotterdam, the Netherlands
Search for more papers by this authorCornelis K. van der Ent MD, PhD
Department of Paediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands
Search for more papers by this authoron behalf of the COMBO-Rint Research Group
COMBO-Rint Research Group members are listed in the Acknowledgment Section.
Search for more papers by this authorAbstract
Bronchial hyperresponsiveness (BHR) is a key feature of asthma and is assessed using bronchial provocation tests. The primary outcome in such tests (a 20% decrease in forced expiratory volume in 1 sec (FEV1)) is difficult to measure in young patients. This study evaluated the sensitivity and specificity of the interrupter resistance (Rint) technique, which does not require active patient participation, by comparing it to the primary outcome measure.
Methacholine challenge tests were performed in children with a history of moderate asthma and BHR. Mean and individual changes in Rint and FEV1 were studied. A receiver operating characteristic (ROC) curve was used to describe sensitivity and specificity of Rint.
Seventy-three children (median age: 9.2 years; range: 6.3–13.4 years) participated. There was a significant (P < 0.01) increase in mean Rint with increasing methacholine doses. However, individual changes of Rint showed large fluctuations. There was great overlap in change of Rint between children who did and did not reach the FEV1 endpoint. A ROC curve showed an area under the curve of 0.65.
Because of low sensitivity and specificity, the use of Rint to diagnose BHR in individual patients seems limited. Pediatr Pulmonol. 2011; 46:266–271. © 2011 Wiley-Liss, Inc.
Supporting Information
Additional Supporting Information may be found in the online version of this article.
| Filename | Description |
|---|---|
| PPUL_21362_sm_SuppData.doc64.5 KB | Supplementary Data |
| PPUL_21362_sm_SuppFig1A.tif80.6 KB | Supplementary Figure 1 |
| PPUL_21362_sm_SuppFig1B.tif89.2 KB | Supplementary Figure 2 |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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