Investigating racial disparities in quality-of-life years after pediatric hematopoietic stem cell transplant
Anuj Shah
University of Miami, Miller School of Medicine, Department of Pediatrics, Miami, Florida, USA
Search for more papers by this authorChristina Regan
The University of Arizona, College of Medicine, Department of Child Health, Phoenix, Arizona, USA
Search for more papers by this authorSerena Suwarno
The University of Arizona, College of Medicine, Department of Child Health, Phoenix, Arizona, USA
Search for more papers by this authorJanet Foote
The University of Arizona, College of Medicine, Department of Child Health, Phoenix, Arizona, USA
Search for more papers by this authorVictoria Bernaud
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorJennifer Stahlecker
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorHolly Miller
The University of Arizona, College of Medicine, Department of Child Health, Phoenix, Arizona, USA
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorNatalie Booth
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorDaniella Giralt
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorDana Salzberg
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorMohamad G. Sinno
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorCourtney Campbell
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorKristen Beebe
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorCharlotte Schwalbach
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorRoberta H. Adams
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorCorresponding Author
Alexander Ngwube
The University of Arizona, College of Medicine, Department of Child Health, Phoenix, Arizona, USA
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Correspondence
Alexander Ngwube, Phoenix Children's Hospital, 1919 E Thomas Rd, Phoenix, AZ 85016, USA.
Email: [email protected]
Search for more papers by this authorAnuj Shah
University of Miami, Miller School of Medicine, Department of Pediatrics, Miami, Florida, USA
Search for more papers by this authorChristina Regan
The University of Arizona, College of Medicine, Department of Child Health, Phoenix, Arizona, USA
Search for more papers by this authorSerena Suwarno
The University of Arizona, College of Medicine, Department of Child Health, Phoenix, Arizona, USA
Search for more papers by this authorJanet Foote
The University of Arizona, College of Medicine, Department of Child Health, Phoenix, Arizona, USA
Search for more papers by this authorVictoria Bernaud
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorJennifer Stahlecker
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorHolly Miller
The University of Arizona, College of Medicine, Department of Child Health, Phoenix, Arizona, USA
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorNatalie Booth
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorDaniella Giralt
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorDana Salzberg
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorMohamad G. Sinno
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorCourtney Campbell
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorKristen Beebe
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorCharlotte Schwalbach
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorRoberta H. Adams
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Search for more papers by this authorCorresponding Author
Alexander Ngwube
The University of Arizona, College of Medicine, Department of Child Health, Phoenix, Arizona, USA
Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona, USA
Correspondence
Alexander Ngwube, Phoenix Children's Hospital, 1919 E Thomas Rd, Phoenix, AZ 85016, USA.
Email: [email protected]
Search for more papers by this authorAbstract
Background
While racial disparities in the clinical outcomes of hematopoietic stem cell transplant (HSCT) patients have been explored, racial disparities in quality of life (QoL) during the re-adjustment phase after transplant are yet to be investigated in pediatric patients. The objective of this study was to examine the role of patient race in QoL at least 2 years after pediatric HSCT.
Procedure
We conducted a retrospective chart review of patients under 21 years of age at diagnosis who received an allogeneic transplant at our institution between January 2007 and December 2017. Patient QoL was assessed using the Pediatric Quality-of-Life Inventory Generic Score Scales (PedsQL TM 4.0) at least 2 years post transplant. Patient demographic, treatment, and transplant outcome data were obtained for subsequent analysis, where patient race was categorized as either Black, White, Hispanic, or Native American.
Results
Data were collected on 86 pediatric patients who underwent HSCT. Forty patients (46.5%) were non-Hispanic White, 29 (33.7%) Hispanic, 10 (11.6%) Black, and seven (8.1%) Native American. Where preliminary analyses indicated a difference in QoL by patient race, there were no significant differences in physical, emotional, social, and school functioning by patient race after adjusting for transplant characteristics (age at transplant, sex, diagnosis, donor type, and conditioning regimen) and determinants of socioeconomic status (insurance type, estimated household income).
Conclusions
Pediatric patients had comparable QoL, regardless of race, at a median of 3 years after HSCT in our study cohort.
CONFLICT OF INTEREST STATEMENT
The authors declare they have no conflicts of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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