Volume 69, Issue 11 e29849

ONCOLOGY: RESEARCH ARTICLE

Asphericity of tumor [¹²³I]mIBG uptake as a prognostic factor in high-risk neuroblastoma

Mikhail Yadgarov,

Corresponding Author

Mikhail Yadgarov

[email protected]

orcid.org/0000-0003-3792-1682

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia

Correspondence

Mikhail Yadgarov, Department of PET and Radionuclide Diagnostics, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela Str. 1, 117997, Moscow, Russia.

Email: [email protected]

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Chaurasiya Kailash,

Chaurasiya Kailash

orcid.org/0000-0002-7427-4560

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia

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Tatyana Shamanskaya,

Tatyana Shamanskaya

orcid.org/0000-0002-3767-4477

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia

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Denis Kachanov,

Denis Kachanov

orcid.org/0000-0002-3704-8783

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia

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Yury Likar,

Yury Likar

orcid.org/0000-0002-6158-2222

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia

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Mikhail Yadgarov,

Corresponding Author

Mikhail Yadgarov

[email protected]

orcid.org/0000-0003-3792-1682

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia

Correspondence

Email: [email protected]

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Chaurasiya Kailash,

Chaurasiya Kailash

orcid.org/0000-0002-7427-4560

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia

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Tatyana Shamanskaya,

Tatyana Shamanskaya

orcid.org/0000-0002-3767-4477

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia

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Denis Kachanov,

Denis Kachanov

orcid.org/0000-0002-3704-8783

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia

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Yury Likar,

Yury Likar

orcid.org/0000-0002-6158-2222

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia

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First published: 21 June 2022

https://doi.org/10.1002/pbc.29849

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Abstract

Background

In recent years, many research groups have attempted to identify a subgroup of “ultra-high risk” patients within the high-risk neuroblastoma (NB) category. The aim of our study was to evaluate the prognostic significance of parameters derived from pretherapeutic ¹²³I-meta-iodobenzylguanidine ([¹²³I]mIBG) integrated single photon emission computed tomography and computed tomography in high-risk patients with NB.

Methods

The established parameters metabolic tumor volume (MTV), maximal standardized uptake value (SUV_max) and the novel parameter tumor asphericity as well as clinical (age, stage) and genetic factors (1p/11q deletions and MYCN amplification) were analyzed in this single-center retrospective study of high-risk patients with newly diagnosed NB. Univariate/multivariable Cox regression and propensity score matching were performed for clinical and radiological parameters.

Results

Twenty-eight high-risk patients with NB were included (14 males, median age 28.8 (11.3–41.0), range 3–74 months). Multivariable analysis of “full” cohort identified high asphericity (≥65%, adjusted hazard ratio [HR] 5.32, 95% confidence interval [CI]: 1.18–24.07, p = .03) and MTV (≥50 ml, adjusted HR 4.31, 95% CI: 1.18–15.80, p = .027) as the only factors associated with worse event-free survival. In matched cohort, tumor asphericity was a significant predictor of relapse/progression (HR 3.83, 95% CI: 1.03–14.26, p = .046).

Conclusion

In this exploratory study, imaging parameters related to tumor metabolic activity, tumor asphericity and MTV, provided prognostic value for event-free survival in high-risk NB patients. Asphericity ≥65% and MTV ≥50 ml may serve as additional prognostic factors to those already used.

CONFLICT OF INTEREST

The authors declare that there is no conflict of interest.

Open Research

DATA AVAILABILITY STATEMENT

The data supporting the findings of this study are available within the article. Further inquiries can be directed to the corresponding author.

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Volume69, Issue11

November 2022

e29849

Asphericity of tumor [¹²³I]mIBG uptake as a prognostic factor in high-risk neuroblastoma

Abstract

Background

Methods

Results

Conclusion

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

References

Information

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Asphericity of tumor [123I]mIBG uptake as a prognostic factor in high-risk neuroblastoma

Abstract

Background

Methods

Results

Conclusion

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

References

Related

Information

Asphericity of tumor [¹²³I]mIBG uptake as a prognostic factor in high-risk neuroblastoma