Volume 51, Issue 6 pp. 824-825

Brief Report

Octreotide therapy in asparaginase-associated pancreatitis in childhood acute lymphoblastic leukemia

Shu-Fen Wu MD,

Shu-Fen Wu MD

Division of Pediatric Gastroenterology, China Medical University Hospital, Taichung, Taiwan

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An-Chyi Chen MD,

An-Chyi Chen MD

Division of Pediatric Gastroenterology, China Medical University Hospital, Taichung, Taiwan

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Ching-Tien Peng MD,

Ching-Tien Peng MD

Division of Pediatric Hematology and Oncology, Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan

Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan

Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan

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Kang-Hsi Wu MD,

Corresponding Author

Kang-Hsi Wu MD

[email protected]

Division of Pediatric Hematology and Oncology, Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan

Division of Pediatric Hematology and Oncology, China Medical University Hospital, 2 Yuh-Der Road, North District, Taichung 404, Taiwan.===Search for more papers by this author

Shu-Fen Wu MD,

Shu-Fen Wu MD

Division of Pediatric Gastroenterology, China Medical University Hospital, Taichung, Taiwan

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An-Chyi Chen MD,

An-Chyi Chen MD

Division of Pediatric Gastroenterology, China Medical University Hospital, Taichung, Taiwan

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Ching-Tien Peng MD,

Ching-Tien Peng MD

Division of Pediatric Hematology and Oncology, Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan

Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan

Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan

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Kang-Hsi Wu MD,

Corresponding Author

Kang-Hsi Wu MD

[email protected]

Division of Pediatric Hematology and Oncology, Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan

Division of Pediatric Hematology and Oncology, China Medical University Hospital, 2 Yuh-Der Road, North District, Taichung 404, Taiwan.===Search for more papers by this author

First published: 09 October 2008

https://doi.org/10.1002/pbc.21721

Citations: 27

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Abstract

Little is known about octreotide therapy in asparaginase-associated pancreatitis (AAP) in children. Of the 59 children with acute lymphoblastic leukemia (ALL) receiving E. coli L-asparaginase, 5 patients (8.5%) developed AAP. Octreotide was administered to four patients. Clinical and laboratory improvement were evident after octreotide therapy. There were no deaths and no severe adverse side effects were noted. No pseudocysts were detected; however, two of the four patients developed diabetes. One child without octreotide treatment developed chronic pancreatitis and pseudocyst. We conclude that octreotide therapy appears to be safe and potentially beneficial in the management of AAP in children. Pediatr Blood Cancer 2008;51:824–825. © 2008 Wiley-Liss, Inc.

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Volume51, Issue6

December 2008

Pages 824-825

Octreotide therapy in asparaginase-associated pancreatitis in childhood acute lymphoblastic leukemia

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Octreotide therapy in asparaginase-associated pancreatitis in childhood acute lymphoblastic leukemia

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