Intracerebral small round cell tumor: An unusual case with EWS-WT1 translocation
Karim Bouchireb MD
Department of Pediatric and Adolescent Oncology, Institut Gustave Roussy, Villejuif, France
Search for more papers by this authorNathalie Auger PhD
Department of Clinical Biology, Institut Gustave Roussy, Villejuif, France
Search for more papers by this authorRanjeev Bhangoo MD
University Paris Sud, UPRES EA3535 “Pharmacology and new treatments of cancer”, Institut Gustave Roussy, Villejuif, France
Search for more papers by this authorFederico Di Rocco MD
Department of Neurosurgery, Hopital Necker, Paris, France
Search for more papers by this authorNicole Brousse MD
Centre de Ressources Biologiques, Département d'Anatomie Pathologique, Hôpital Necker—Enfants Malades, Paris, France
Search for more papers by this authorOlivier Delattre PhD
Laboratoire de pathologie moléculaire des cancers, Institut Curie, Paris, France
Search for more papers by this authorPascale Varlet MD
Laboratoire de Neuropathologie, Centre Hospitalier Sainte Anne, Paris, France
Search for more papers by this authorCorresponding Author
Jacques Grill MD, PhD
University Paris Sud, UPRES EA3535 “Pharmacology and new treatments of cancer”, Institut Gustave Roussy, Villejuif, France
Institut Gustave Roussy-Pediatric and Adolescent Oncology 39, rue Camille Desmoulins Villejuif 94805, France.===Search for more papers by this authorKarim Bouchireb MD
Department of Pediatric and Adolescent Oncology, Institut Gustave Roussy, Villejuif, France
Search for more papers by this authorNathalie Auger PhD
Department of Clinical Biology, Institut Gustave Roussy, Villejuif, France
Search for more papers by this authorRanjeev Bhangoo MD
University Paris Sud, UPRES EA3535 “Pharmacology and new treatments of cancer”, Institut Gustave Roussy, Villejuif, France
Search for more papers by this authorFederico Di Rocco MD
Department of Neurosurgery, Hopital Necker, Paris, France
Search for more papers by this authorNicole Brousse MD
Centre de Ressources Biologiques, Département d'Anatomie Pathologique, Hôpital Necker—Enfants Malades, Paris, France
Search for more papers by this authorOlivier Delattre PhD
Laboratoire de pathologie moléculaire des cancers, Institut Curie, Paris, France
Search for more papers by this authorPascale Varlet MD
Laboratoire de Neuropathologie, Centre Hospitalier Sainte Anne, Paris, France
Search for more papers by this authorCorresponding Author
Jacques Grill MD, PhD
University Paris Sud, UPRES EA3535 “Pharmacology and new treatments of cancer”, Institut Gustave Roussy, Villejuif, France
Institut Gustave Roussy-Pediatric and Adolescent Oncology 39, rue Camille Desmoulins Villejuif 94805, France.===Search for more papers by this authorAbstract
Desmoplastic small round cell tumor (DSRCT) is a rare tumor, seen both in children and young adults with a marked predilection for the peritoneal cavity. Histology showed a small round cell tumor with a fibromyxoïd stroma and immunohistochemistry indicated neural and mesenchymal differentiation, and diagnosis was made by molecular detection of the EWS-WT1 fusion gene product. DSRCT should be considered in the differential diagnosis of intracranial small round cell tumors. Pediatr Blood Cancer 2008;51:545–548. © 2008 Wiley-Liss, Inc.
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