RESEARCH ARTICLE
A Feasibility Study on the Use of UV-Curable Resins for Long-Acting Monitoring Microneedle Substrates
Baoling Jia,
Tiandong Xia,
Xiaohui Wang,
Yangtao Xu,
Bei Li,
Corresponding Author
Baoling Jia
School of Materials Science and Engineering, Lanzhou University of Technology, Lanzhou, China
State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metal Under the Province and the Ministry of Education, Lanzhou University of Technology, Lanzhou, China
Correspondence:
Baoling Jia ([email protected])
Tiandong Xia ([email protected])
Search for more papers by this authorCorresponding Author
Tiandong Xia
School of Materials Science and Engineering, Lanzhou University of Technology, Lanzhou, China
State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metal Under the Province and the Ministry of Education, Lanzhou University of Technology, Lanzhou, China
Correspondence:
Baoling Jia ([email protected])
Tiandong Xia ([email protected])
Search for more papers by this authorXiaohui Wang
Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China
Search for more papers by this authorYangtao Xu
School of Materials Science and Engineering, Lanzhou University of Technology, Lanzhou, China
State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metal Under the Province and the Ministry of Education, Lanzhou University of Technology, Lanzhou, China
Search for more papers by this authorBei Li
School of Materials Science and Engineering, Lanzhou University of Technology, Lanzhou, China
Search for more papers by this authorBaoling Jia,
Tiandong Xia,
Xiaohui Wang,
Yangtao Xu,
Bei Li,
Corresponding Author
Baoling Jia
School of Materials Science and Engineering, Lanzhou University of Technology, Lanzhou, China
State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metal Under the Province and the Ministry of Education, Lanzhou University of Technology, Lanzhou, China
Correspondence:
Baoling Jia ([email protected])
Tiandong Xia ([email protected])
Search for more papers by this authorCorresponding Author
Tiandong Xia
School of Materials Science and Engineering, Lanzhou University of Technology, Lanzhou, China
State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metal Under the Province and the Ministry of Education, Lanzhou University of Technology, Lanzhou, China
Correspondence:
Baoling Jia ([email protected])
Tiandong Xia ([email protected])
Search for more papers by this authorXiaohui Wang
Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China
Search for more papers by this authorYangtao Xu
School of Materials Science and Engineering, Lanzhou University of Technology, Lanzhou, China
State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metal Under the Province and the Ministry of Education, Lanzhou University of Technology, Lanzhou, China
Search for more papers by this authorBei Li
School of Materials Science and Engineering, Lanzhou University of Technology, Lanzhou, China
Search for more papers by this authorFirst published: 10 December 2024
Funding: This work was supported by Major Science and Technology Projects of Gansu Province, China (22ZD6GA008).
ABSTRACT
Microneedle (MN) has significant potential for transdermal glucose monitoring. However, challenges remain in selecting suitable materials for long-acting monitoring MN. In this study, precise solid UV-curable resin MN patches were fabricated using a synergistic combination of the micromolding method and the UV-curing procedure, as an alternative to the previous 3D printing. The properties of the UV-cured resin MN patches prepared using this method were evaluated and characterized, focusing on their potential for long-acting monitoring. The results demonstrated that the UV-curable resin MN patches exhibited superior shape stability, very low cytotoxicity, minimal skin irritation, and a fracture force of approximately 2.289 N/needle. Following immersion in 37°C PBS for different days, the shape and mass changed negligibly, and the fracture force still reached half of the original values after 21 days. UV-curable resin is a highly promising substrate for MN, and the study provides a new material selection strategy for long-acting monitoring of MN development.
Conflicts of Interest
The authors declare no conflicts of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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