Volume 25, Issue 11 pp. 1216-1225
Special issue: Review

Polymeric nanoparticles for therapy and imaging

Wenjie He

Wenjie He

Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology (Taiwan Tech), Taipei, 10607 Taiwan

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Hossein Hosseinkhani

Corresponding Author

Hossein Hosseinkhani

Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology (Taiwan Tech), Taipei, 10607 Taiwan

Nanomedicine Research Center of Taiwan, Research Center for Biomedical devices and Prototyping Production, Research Center for Biomedical Implants and Microsurgery Devices, Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, and Department of Dentistry, Taipei Medical University-Shuang-Ho Hospital, Taipei, 110 Taiwan

Correspondence to: Dr. Hossein Hosseinkhani, Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology (Taiwan Tech), Taipei 10607, Taiwan.

E-mail: [email protected]

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Reza Mohammadinejad

Reza Mohammadinejad

Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology (Taiwan Tech), Taipei, 10607 Taiwan

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Ziba Roveimiab

Ziba Roveimiab

Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology (Taiwan Tech), Taipei, 10607 Taiwan

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Dueng-Yuan Hueng

Dueng-Yuan Hueng

Department of Biochemistry, National Defense Medical Center, Department of Neurological Surgery, Tri-Service General Hospital, Taipei, 114 Taiwan

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Keng-Liang Ou

Keng-Liang Ou

Nanomedicine Research Center of Taiwan, Research Center for Biomedical devices and Prototyping Production, Research Center for Biomedical Implants and Microsurgery Devices, Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, and Department of Dentistry, Taipei Medical University-Shuang-Ho Hospital, Taipei, 110 Taiwan

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Abraham J. Domb

Abraham J. Domb

Institute of Drug Research, The Center for Nanoscience and Nanotechnology, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120 Israel

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First published: 07 October 2014
Citations: 51

This article is published in Journal of Polymers for Advanced Technologies as a special issue on 12th PAT Conference in Berlin, 2013, edited by Prof. Andreas Lendlein and Prof. Marc Behl, Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht GmbH, Centre for Materials and Coastal Research, Kantstr. 55, 14513 Teltow, Germany.

Abstract

Polymeric nanoparticles and their applications have been studied over the long period. Polymeric nanoparticles have been shown to be promising carriers for drug delivery because of their potential in encapsulating drugs hence protecting them from excretion and metabolism. Different polymers have been used, and different strategies such as surface modification have been carried out to increase the retention time of nanoparticles and to increase therapeutic benefit while minimizing side effects. Here, we review aspects of polymeric nanoparticles and their application in magnetic resonance imaging technology, disease therapy, drug delivery systems, and gene transfer. Copyright © 2014 John Wiley & Sons, Ltd.

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